Liver transplantation for tumor entities.

IF 1.8 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2024-08-01 Epub Date: 2024-05-08 DOI:10.1097/MOT.0000000000001149

Damiano Patrono, Nicola De Stefano, Renato Romagnoli

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引用次数: 0

Abstract

Purpose of review: Tumor entities represent an increasing indication for liver transplantation (LT). This review addresses the most contentious indications of LT in transplant oncology.

Recent findings: Patient selection based on tumor biology in LT for colorectal cancer liver metastases (CRLM) demonstrated promising long-term outcomes and preserved quality of life despite high recurrence rates. In selected cases, LT for intrahepatic cholangiocarcinoma (iCCA) is feasible, with acceptable survival even in high-burden cases responsive to chemotherapy. LT following a strict neoadjuvant protocol for perihilar cholangiocarcinoma (pCCA) resulted in long-term outcomes consistently surpassing benchmark values, and potentially outperforming liver resection.

Summary: While preliminary results are promising, prospective trials are crucial to define applications in routine clinical practice. Molecular profiling and targeted therapies pave the way for personalized approaches, requiring evolving allocation systems for equitable LT access.

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肿瘤实体肝移植。

审查目的：肿瘤实体是肝移植（LT）越来越多的适应症。本综述探讨了移植肿瘤学中最有争议的肝移植适应症：尽管复发率较高，但在治疗结直肠癌肝转移（CRLM）的肝移植中，基于肿瘤生物学的患者选择显示出良好的长期疗效和生活质量。在经过选择的病例中，肝内胆管癌（iCCA）的LT治疗是可行的，即使是对化疗有反应的高负担病例，其生存率也是可以接受的。对肝周胆管癌（pCCA）采用严格的新辅助方案进行LT治疗，其长期疗效一直超过基准值，并有可能优于肝切除术。摘要：虽然初步结果令人鼓舞，但前瞻性试验对于确定常规临床实践中的应用至关重要。分子图谱分析和靶向治疗为个性化方法铺平了道路，需要不断发展的分配系统来实现公平的LT使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.