[Early Detection Of Type 1 Diabetes By Islet Autoantibody Screening: A Position Paper Of The Fr1daplex Project Leaders And Training Centres, Bvkj Bavaria And Paednetz (Registered) Bavaria].

IF 0.7 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Gesundheitswesen Pub Date : 2024-07-29 DOI:10.1055/a-2320-2859

Peter Achenbach, Reinhard Berner, Ezio Bonifacio, Susanne Brämswig, Sonja Braig, Desiree Dunstheimer, Uwe Ermer, Dominik Ewald, Gita Gemulla, Julia Hauer, Florian Haupt, Gabi Haus, Michael Hubmann, Sandra Hummel, Michael Kandler, Olga Kordonouri, Karin Lange, Otto Laub, Anja Lorrmann, Nicole Nellen-Hellmuth, Marina Sindichakis, Thekla von dem Berge, Katharina Warncke, Leonie Weber, Christiane Winkler, Philip Wintermeyer, Anette-Gabriele Ziegler

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Abstract

This position paper is based on the authors' many years of clinical experience and basic science research on the diagnosis and treatment of children and adolescents with a presymptomatic early stage of type 1 diabetes. The benefits as well as potential disadvantages of early detection of type 1 diabetes by islet autoantibody screening are critically discussed. In addition, the perspectives of delaying the onset of the clinical metabolic disease through treatment with teplizumab are addressed. Today, we see the chance for a relevant improvement in therapeutic options and life perspectives of affected children and adolescents. Important next steps for the implementation of islet autoantibody screening in Germany are the training of pediatricians who should inform families about the screening, establishment of a few transregional laboratories that carry out the test, and expansion of regional capacities for the training and care of children with an early stage of type 1 diabetes.

查看原文本刊更多论文

通过胰岛自身抗体筛查早期发现 1 型糖尿病 - Fr1daPlex 项目负责人和培训中心 BVKJ Bayern 和 PaedNetz Bayern e.V. 的立场文件。

本立场文件基于作者多年的临床经验和基础科学研究，针对儿童和青少年无症状早期 1 型糖尿病患者的诊断和治疗。文章对通过胰岛自身抗体筛查早期发现 1 型糖尿病的益处和潜在弊端进行了深入探讨。此外，还探讨了通过使用替普利珠单抗治疗来延缓临床代谢疾病发病的前景。如今，我们看到了改善治疗方案和受影响儿童和青少年生活前景的机会。在德国实施胰岛自身抗体筛查的下一个重要步骤是培训儿科医生，让他们告知家庭有关筛查的信息，建立几个跨地区的实验室来进行检测，以及扩大地区培训和护理 1 型糖尿病早期儿童的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gesundheitswesen PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

1.90

自引率

18.20%

发文量

308

期刊介绍： The health service informs you comprehensively and up-to-date about the most important topics of the health care system. In addition to guidelines, overviews and comments, you will find current research results and contributions to CME-certified continuing education and training. The journal offers a scientific discussion forum and a platform for communications from professional societies. The content quality is ensured by a publisher body, the expert advisory board and other experts in the peer review process.

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