Brandon Ebright, Marlon V Duro, Kai Chen, Stan Louie, Hussein N Yassine
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引用次数: 0
Abstract
Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity. As Alzheimer's disease (AD) pathology progresses, DHA metabolism in the brain becomes dysregulated, the timing and extent of which may be influenced by the apolipoprotein E ε4 (APOE4) allele. Here, we discuss how maintaining adequate DHA intake early in life may slow the progression to AD dementia in cognitively normal individuals with APOE4, how recent advances in DHA brain imaging could offer insights leading to more personalized preventive strategies, and how alternative strategies targeting PUFA metabolism pathways may be more effective in mitigating disease progression in patients with existing AD dementia.
欧米伽-3（n-3）多不饱和脂肪酸（PUFA），如二十二碳六烯酸（DHA），通过促进神经元功能、维持炎症平衡和提供结构完整性，在人类营养和大脑健康中发挥着重要作用。随着阿尔茨海默病（AD）病理的发展，大脑中的 DHA 代谢会出现失调，其发生的时间和程度可能会受到载脂蛋白 E ε4（APOE4）等位基因的影响。在此，我们将讨论在生命早期保持足够的 DHA 摄入量可如何减缓认知正常的 APOE4 患者向 AD 痴呆症的进展，DHA 脑成像的最新进展可如何为制定更个性化的预防策略提供启示，以及针对 PUFA 代谢途径的替代策略可如何更有效地缓解现有 AD 痴呆症患者的疾病进展。
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