Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report.

IF 2.1 4区生物学 Q4 CELL BIOLOGY

European Journal of Histochemistry Pub Date : 2024-05-02 DOI:10.4081/ejh.2024.3994

Claudia Lombardo, Grazia Maugeri, Agata Grazia D'Amico, Giuseppe Broggi, Rosario Caltabiano, Veronica Filetti, Serena Matera, Velia D'Agata, Carla Loreto

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引用次数: 0

Abstract

Pleural mesothelioma is a devastating malignancy primarily associated with asbestos exposure. However, emerging evidence suggests that exposure to fluoro-edenite fibers, a naturally occurring mineral fiber, can also lead to the development of pleural mesothelioma. In this study, based on the hypothesis that pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-preferring receptor (PAC1R) expressions could be dysregulated in pleural mesothelioma samples and that they could potentially act as diagnostic or prognostic biomarkers, we aimed to investigate the immunohistochemical expression of PACAP and PAC1R in pleural biopsies from patients with pleural mesothelioma exposed to fluoro-edenite fibers. A total of 12 patients were included in this study, and their biopsies were processed for immunohistochemical analysis to evaluate the expression of PACAP and its receptor. The study revealed a correlation between the overexpression of PACAP and PAC1R and shorter overall survival in patients with malignant mesothelioma. These findings suggest that PACAP and PAC1R expression levels could serve as potential prognostic biomarkers for malignant mesothelioma. Furthermore, the immunohistochemical analysis of PACAP and PAC1R may provide valuable information for clinicians to guide therapeutic decisions and identify patients with poorer prognosis.

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接触氟烯酸盐导致的胸膜间皮瘤：PACAP 和 PAC1 受体。初步报告。

胸膜间皮瘤是一种破坏性恶性肿瘤，主要与接触石棉有关。然而，新的证据表明，接触氟烯酸纤维（一种天然矿物纤维）也会导致胸膜间皮瘤的发生。在本研究中，我们假设垂体腺苷酸环化酶激活多肽（PACAP）和 PACAP 优先受体（PAC1R）的表达可能在胸膜间皮瘤样本中失调，并且它们有可能作为诊断或预后的生物标志物、我们旨在研究暴露于氟烯酸纤维的胸膜间皮瘤患者胸膜活检组织中 PACAP 和 PAC1R 的免疫组化表达。本研究共纳入了 12 例患者，并对其活检组织进行了免疫组化分析，以评估 PACAP 及其受体的表达情况。研究发现，PACAP 和 PAC1R 的过表达与恶性间皮瘤患者较短的总生存期之间存在相关性。这些发现表明，PACAP 和 PAC1R 的表达水平可作为恶性间皮瘤的潜在预后生物标志物。此外，PACAP和PAC1R的免疫组化分析可为临床医生提供有价值的信息，以指导治疗决策并识别预后较差的患者。

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来源期刊

European Journal of Histochemistry 生物-细胞生物学

CiteScore

3.70

自引率

5.00%

发文量

审稿时长

3 months

期刊介绍： The Journal publishes original papers concerning investigations by histochemical and immunohistochemical methods, and performed with the aid of light, super-resolution and electron microscopy, cytometry and imaging techniques. Coverage extends to: functional cell and tissue biology in animals and plants; cell differentiation and death; cell-cell interaction and molecular trafficking; biology of cell development and senescence; nerve and muscle cell biology; cellular basis of diseases. The histochemical approach is nowadays essentially aimed at locating molecules in the very place where they exert their biological roles, and at describing dynamically specific chemical activities in living cells. Basic research on cell functional organization is essential for understanding the mechanisms underlying major biological processes such as differentiation, the control of tissue homeostasis, and the regulation of normal and tumor cell growth. Even more than in the past, the European Journal of Histochemistry, as a journal of functional cytology, represents the venue where cell scientists may present and discuss their original results, technical improvements and theories.