Neoadjuvant nivolumab plus chemotherapy followed by resection for superior sulcus tumour with high PD-L1 expression: A case report.

IF 0.8 Q4 RESPIRATORY SYSTEM
Respirology Case Reports Pub Date : 2024-04-25 eCollection Date: 2024-05-01 DOI:10.1002/rcr2.1358
Takahito Nakaya, Yoshimitsu Hirai, Hiroaki Akamatsu, Fumiyoshi Kojima, Hideto Iguchi, Aya Fusamoto, Yumi Yata, Takahiro Nagai, Daiki Kitahara, Toshiaki Takakura, Yoshiharu Nishimura, Nobuyuki Yamamoto
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引用次数: 0

Abstract

The standard treatment for resectable non-small cell lung cancer (NSCLC) located in the superior sulcus is neoadjuvant chemoradiotherapy followed by highly invasive resection. Based on the results of the CheckMate 816 trial, which showed a marked improvement in the efficacy of neoadjuvant chemo-immunotherapy, we report a case of minimally invasive resection after neoadjuvant nivolumab plus chemotherapy for superior sulcus NSCLC, resulting in a pathologic complete response. The patient was a 76-year-old man with a 65-mm right superior sulcus tumour diagnosed as squamous cell carcinoma with 95% PD-L1. After two courses of neoadjuvant nivolumab plus chemotherapy, the tumour was completely resected through an 11-cm right lateral thoracotomy with second rib resection and first rib preservation. No residual tumour cells were observed in the specimen, and the patient had a pathologic complete response. This report represents a new treatment option for superior sulcus tumours.

新辅助nivolumab加化疗后切除PD-L1高表达的上沟肿瘤:病例报告。
对于位于上沟部的可切除非小细胞肺癌(NSCLC),标准治疗方法是先进行新辅助化放疗,然后进行高创切除。CheckMate 816 试验结果表明,新辅助化疗免疫疗法的疗效显著提高,基于这一结果,我们报告了一例上沟区 NSCLC 患者在新辅助 nivolumab 加化疗后行微创切除术并获得病理完全反应的病例。患者是一名76岁的男性,右上沟肿瘤65毫米,诊断为鳞癌,95%为PD-L1。经过两个疗程的新辅助尼伐单抗加化疗后,通过11厘米的右侧胸廓切开术完全切除了肿瘤,并切除了第二根肋骨,保留了第一根肋骨。标本中未观察到残留肿瘤细胞,患者获得了病理完全反应。该报告为上沟肿瘤提供了一种新的治疗方案。
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来源期刊
Respirology Case Reports
Respirology Case Reports RESPIRATORY SYSTEM-
CiteScore
1.40
自引率
0.00%
发文量
178
审稿时长
8 weeks
期刊介绍: Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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