Cellotype-phenotype associations using 'organoid villages'.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-04-03 DOI:10.1016/j.tem.2024.03.001

Masaki Kimura, Takanori Takebe

引用次数: 0

Abstract

En masse phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype-phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, inform genetic-epigenetic interactions and identify personalized therapeutic targets, offering hope for precision medicine against highly heterogeneous metabolic diseases.

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利用 "类器官村 "实现细胞型与表型的关联。

大规模表型技术使用大规模镶嵌的供体衍生细胞和器官组织，可在细胞类型特异性调控背景下提供细胞型-表型关联的丰富见解。这种新兴方法将有助于发现生物标志物，为遗传-表观遗传相互作用提供信息，并确定个性化治疗靶点，为针对高度异质性代谢性疾病的精准医疗带来希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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