Polyethylene terephthalate nanoplastics cause oxidative stress induced cell death in Saccharomyces cerevisiae.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2024-05-01 DOI:10.1080/10934529.2024.2345026

Nur Kaluç, E Lal Çötelli, Salih Tuncay, Pınar B Thomas

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Abstract

Polyethylene terephthalate (PET) is a common plastic widely used in food and beverage packaging that poses a serious risk to human health and the environment due to the continual rise in its production and usage. After being produced and used, PET accumulates in the environment and breaks down into nanoplastics (NPs), which are then consumed by humans through water and food sources. The threats to human health and the environment posed by PET-NPs are of great concern worldwide, yet little is known about their biological impacts. Herein, the smallest sized PET-NPs so far (56 nm) with an unperturbed PET structure were produced by a modified dilution-precipitation method and their potential cytotoxicity was evaluated in Saccharomyces cerevisiae. Exposure to PET-NPs decreased cell viability due to oxidative stress induction revealed by the increased expression levels of stress response related-genes as well as increased lipid peroxidation. Cell death induced by PET-NP exposure was mainly through apoptosis, while autophagy had a protective role.

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聚对苯二甲酸乙二醇酯纳米塑料在酿酒酵母中导致氧化应激诱导的细胞死亡。

聚对苯二甲酸乙二醇酯（PET）是一种广泛用于食品和饮料包装的常见塑料，由于其产量和用量持续增加，对人类健康和环境构成了严重威胁。PET 在生产和使用后会在环境中积累并分解成纳米塑料 (NP)，然后通过水和食物来源被人类摄入。PET-NPs 对人类健康和环境造成的威胁引起了全世界的高度关注，但人们对其生物影响却知之甚少。本文采用改良的稀释沉淀法制备了迄今为止尺寸最小（56 nm）且 PET 结构未受干扰的 PET-NPs，并在酿酒酵母中评估了其潜在的细胞毒性。暴露于 PET-NPs 会降低细胞活力，原因是应激反应相关基因的表达水平升高以及脂质过氧化反应加剧，从而诱发氧化应激。暴露于 PET-NP 引发的细胞死亡主要是通过细胞凋亡，而自噬起着保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.