Exploring melatonin’s multifaceted role in female reproductive health: From follicular development to lactation and its therapeutic potential in obstetric syndromes

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2024-04-30 DOI:10.1016/j.jare.2024.04.025

Qihui Li , Tenghui Zheng , Jiaming Chen , Baofeng Li , Qianzi Zhang , Siwang Yang , Jiayuan Shao , Wutai Guan , Shihai Zhang

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Abstract

Background

Melatonin is mainly secreted by the pineal gland during darkness and regulates biological rhythms through its receptors in the suprachiasmatic nucleus of the hypothalamus. In addition, it also plays a role in the reproductive system by affecting the function of the hypothalamic-pituitary-gonadal axis, and by acting as a free radical scavenger thus contributing to the maintenance of the optimal physiological state of the gonads. Besides, melatonin can freely cross the placenta to influence fetal development. However, there is still a lack of overall understanding of the role of melatonin in the reproductive cycle of female mammals.

Aim of review

Here we focus the role of melatonin in female reproduction from follicular development to delivery as well as the relationship between melatonin and lactation. We further summarize the potential role of melatonin in the treatment of preeclampsia, polycystic ovary syndrome, endometriosis, and ovarian aging.

Key scientific concepts of review

Understanding the physiological role of melatonin in female reproductive processes will contribute to the advancement of human fertility and reproductive medicine research.

Abstract Image

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探索褪黑激素在女性生殖健康中的多方面作用：从卵泡发育到泌乳及其在产科综合症中的治疗潜力。

背景：褪黑素主要由松果体在黑暗中分泌，通过下丘脑上核的受体调节生物节律。此外，它还通过影响下丘脑-垂体-性腺轴的功能，在生殖系统中发挥作用，并作为自由基清除剂，有助于维持性腺的最佳生理状态。此外，褪黑激素还能自由穿过胎盘影响胎儿发育。然而，人们对褪黑激素在雌性哺乳动物生殖周期中的作用仍缺乏全面的了解：在此，我们重点探讨了褪黑激素在雌性哺乳动物从卵泡发育到分娩的生殖过程中的作用，以及褪黑激素与泌乳之间的关系。我们进一步总结了褪黑激素在治疗子痫前期、多囊卵巢综合症、子宫内膜异位症和卵巢衰老中的潜在作用：了解褪黑激素在女性生殖过程中的生理作用将有助于人类生育和生殖医学研究的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.