T cell responses in immune-mediated IgA nephropathy.

IF 3.6 3区医学 Q3 CELL BIOLOGY

Journal of Leukocyte Biology Pub Date : 2024-09-02 DOI:10.1093/jleuko/qiae103

Shimin Xie, Mengying Sun, Xiaohan Zhang, Chao Kan, Guojuan Shi, Weixiang Peng, Junli Guo, Dantong Wu, Zhinan Yin, Quanli Yang, Rui Zhang

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引用次数: 0

Abstract

Immunoglobulin A nephropathy is a complex autoimmune disease with various underlying causes and significant clinical heterogeneity. There are large individual differences in its development, and the etiology and pathogenesis are still poorly understood. While it is known that immunobiological factors play a significant role in the pathophysiology of immunoglobulin A nephropathy, the specific nature of these factors has yet to be fully elucidated. Numerous investigations have verified that CD4+ and CD8+ T lymphocytes are involved in the immunopathogenesis of immunoglobulin A nephropathy. Furthermore, certain data also point to γδT cells' involvement in the pathophysiology of immunoglobulin A nephropathy. By thoroughly examining the mechanisms of action of these T cells in the context of immunoglobulin A nephropathy, this review sheds light on the immunopathogenesis of the disease and its associated factors. The review is intended to provide reference value for the future research in this field and promising treatment clues for clinical patients.

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免疫介导的 IgA 肾病中的 T 细胞反应。

免疫球蛋白 A 肾病（IgAN）是一种复杂的自身免疫性疾病，其病因多种多样，临床表现具有明显的异质性。该病的发病存在很大的个体差异，病因和发病机制至今仍不十分清楚。虽然已知免疫生物学因素在 IgAN 的病理生理学中起着重要作用，但这些因素的具体性质尚未完全阐明。大量研究已经证实，分化群 4+（CD4+）和 CD8+ T 淋巴细胞参与了 IgAN 的免疫发病机制。此外，某些数据还表明γδT 细胞参与了 IgAN 的病理生理学。通过深入研究这些 T 细胞在 IgAN 中的作用机制，本综述揭示了该疾病的免疫发病机制及其相关因素。本综述旨在为该领域的未来研究提供参考价值，并为临床患者提供有希望的治疗线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Leukocyte Biology 医学-免疫学

CiteScore

11.50

自引率

0.00%

发文量

358

审稿时长

2 months

期刊介绍： JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.