Regional hyperthermia for soft tissue sarcoma - a survey on current practice, controversies and consensus among 12 European centers.

IF 3 3区医学 Q2 ONCOLOGY

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-04-23 DOI:10.1080/02656736.2024.2342348

Siyer Roohani, Felix Ehret, Marcus Beck, Danai P Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D Issels, Stephan Klöck, Robert Krempien, Lars H Lindner, Markus Notter, Oliver J Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips, Pirus Ghadjar, David Kaul

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Abstract

Purpose: To analyze the current practice of regional hyperthermia (RHT) for soft tissue sarcoma (STS) at 12 European centers to provide an overview, find consensuses and identify controversies necessary for future guidelines and clinical trials.

Methods: In this cross-sectional survey study, a 27-item questionnaire assessing clinical subjects and procedural details on RHT for STS was distributed to 12 European cancer centers for RHT.

Results: We have identified seven controversies and five consensus points. Of 12 centers, 6 offer both, RHT with chemotherapy (CTX) or with radiotherapy (RT). Two centers only offer RHT with CTX and four centers only offer RHT with RT. All 12 centers apply RHT for localized, high-risk STS of the extremities, trunk wall and retroperitoneum. However, eight centers also use RHT in metastatic STS, five in palliative STS, eight for superficial STS and six for low-grade STS. Pretherapeutic imaging for RHT treatment planning is used by 10 centers, 9 centers set 40-43 °C as the intratumoral target temperature, and all centers use skin detectors or probes in body orifices for thermometry.

Discussion: There is disagreement regarding the integration of RHT in contemporary interdisciplinary care of STS patients. Many clinical controversies exist that require a standardized consensus guideline and innovative study ideas. At the same time, our data has shown that existing guidelines and decades of experience with the technique of RHT have mostly standardized procedural aspects.

Conclusions: The provided results may serve as a basis for future guidelines and inform future clinical trials for RHT in STS patients.

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软组织肉瘤区域热疗--12 个欧洲中心对当前做法、争议和共识的调查。

目的：分析12个欧洲中心目前对软组织肉瘤（STS）进行区域热疗（RHT）的实践情况，为未来的指南和临床试验提供一个概览，找到共识并找出必要的争议点：在这项横断面调查研究中，我们向 12 个欧洲癌症中心的 RHT 患者发放了一份 27 个项目的调查问卷，评估 STS RHT 的临床对象和手术细节：结果：我们发现了七个争议点和五个共识点。在 12 个中心中，有 6 个中心同时提供 RHT 和化疗 (CTX) 或放疗 (RT)。有两家中心只提供结合 CTX 的 RHT，有四家中心只提供结合 RT 的 RHT。所有 12 个中心都将 RHT 用于四肢、躯干壁和腹膜后的局部高危 STS。不过，也有 8 个中心将 RHT 用于转移性 STS，5 个中心用于姑息性 STS，8 个中心用于浅表性 STS，6 个中心用于低级别 STS。10个中心使用治疗前成像来制定RHT治疗计划，9个中心将40-43 °C作为瘤内目标温度，所有中心都使用皮肤探测器或体腔探头进行测温：讨论：对于将 RHT 纳入 STS 患者的跨学科治疗，目前还存在分歧。许多临床争议需要标准化的共识指南和创新的研究理念。与此同时，我们的数据显示，现有的指南和数十年的 RHT 技术经验已基本实现了程序方面的标准化：所提供的结果可作为未来指南的依据，并为未来 STS 患者 RHT 的临床试验提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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