Spectrum of Pediatric Autoimmune Hepatitis in a Cohort of Pakistani Children.

IF 1.4 Q3 PEDIATRICS

Global Pediatric Health Pub Date : 2024-04-30 eCollection Date: 2024-01-01 DOI:10.1177/2333794X241251644

Sabeen Abid Khan, Naurin Ali, Muhammad Arslan Farooq, Shamama Hasan, Munir Iqbal Malik

{"title":"Spectrum of Pediatric Autoimmune Hepatitis in a Cohort of Pakistani Children.","authors":"Sabeen Abid Khan, Naurin Ali, Muhammad Arslan Farooq, Shamama Hasan, Munir Iqbal Malik","doi":"10.1177/2333794X241251644","DOIUrl":null,"url":null,"abstract":"Background. Autoimmune hepatitis (AIH) is increasingly seen in children worldwide and it is more severe in children compared to adults. This study highlights the biochemical and clinical aspect, treatment given and outcome of the disease including pediatric liver transplantation. Study. Retrospective review (2012-2022) was done in Shifa International Hospital, Islamabad. Patients under 18 years diagnosed with AIH were included. Data related to age, gender, clinical features, laboratory investigations including liver function test, liver biopsy findings and imaging modalities were included. Results. Fifteen patients were included 7 (47%) were males and 8 (53%) females. AIH type 1 was the most common type seen in 7 (46%), AIH type 2 in 5 (33%) and seronegative in 3 (20%). Jaundice was the most common symptom. Liver biopsy showed findings characteristic of AIH. Liver transplant performed in 3 patients. Conclusion. The study highlights the varied clinical presentation of AIH in Pakistani children.","PeriodicalId":12576,"journal":{"name":"Global Pediatric Health","volume":"11 ","pages":"2333794X241251644"},"PeriodicalIF":1.4000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062213/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Pediatric Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2333794X241251644","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background. Autoimmune hepatitis (AIH) is increasingly seen in children worldwide and it is more severe in children compared to adults. This study highlights the biochemical and clinical aspect, treatment given and outcome of the disease including pediatric liver transplantation. Study. Retrospective review (2012-2022) was done in Shifa International Hospital, Islamabad. Patients under 18 years diagnosed with AIH were included. Data related to age, gender, clinical features, laboratory investigations including liver function test, liver biopsy findings and imaging modalities were included. Results. Fifteen patients were included 7 (47%) were males and 8 (53%) females. AIH type 1 was the most common type seen in 7 (46%), AIH type 2 in 5 (33%) and seronegative in 3 (20%). Jaundice was the most common symptom. Liver biopsy showed findings characteristic of AIH. Liver transplant performed in 3 patients. Conclusion. The study highlights the varied clinical presentation of AIH in Pakistani children.

查看原文本刊更多论文

巴基斯坦儿童群体中的小儿自身免疫性肝炎谱。

背景。自身免疫性肝炎（AIH）在全球儿童中的发病率越来越高，与成人相比，儿童的病情更为严重。本研究强调了该病的生化和临床方面、治疗方法和结果，包括小儿肝移植。研究内容伊斯兰堡希法国际医院进行了回顾性研究（2012-2022 年）。研究对象包括被诊断为 AIH 的 18 岁以下患者。研究纳入了与年龄、性别、临床特征、实验室检查（包括肝功能检查）、肝活检结果和影像学检查方式相关的数据。结果。共纳入 15 名患者，其中男性 7 名（占 47%），女性 8 名（占 53%）。7例（46%）最常见的类型为AIH 1型，5例（33%）为AIH 2型，3例（20%）为血清阴性。黄疸是最常见的症状。肝活检显示出 AIH 的特征。3 名患者接受了肝移植手术。结论该研究强调了巴基斯坦儿童 AIH 的各种临床表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Global Pediatric Health Nursing-Pediatrics

CiteScore

2.20

自引率

0.00%

发文量

105

审稿时长

12 weeks