Neuregulin 4 in Polycystic Ovarian Syndrome (PCOS) Phenotypes: A Key Role or Standby.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Afnan Hayder Abbood, Rana Majeed Hameed, Wasan Ghazi Al Safi
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引用次数: 0

Abstract

Background: Neuregulin_4 (NRG4) is one of the adipokines members that synthesize adipose tissues. It has an activating effect on epidermal growth factor receptors (ErbB receptors). NRG4 has indirect effects on the hormonal environment through its interaction to ErbB receptors. Increased insulin resistance and chronic low-grade inflammation may be present when NRG4 levels are high in PCOS. Obesity and polycystic ovarian syndrome have recently gained a lot of attention. However, the literature on the connection between NRG4 and the PCOS phenotype is limited. Thus, this research aimed to identify neuregulin_4's function as a biomarker for insulin resistance in PCOS phenotypes.

Methods: A case-control study and included 140 female cases effect by different phenotypes of PCOS. Patients samples were collected at the reproductive fertility consultant of the Teaching Hospital for Obstetrics and Gynecology, Kerbala health directorate, Iraq. The outpatient clinic serum hormonal levels and insulin concentration were determined by the electrochemiluminescence immunoassay "ECLIA" system. Elisa system was used for the detection of Neuregulin-4 protein level.

Results: At the early age of participant NRG4 was increased significantly in all phenotypes of PCOS compared to control with a P< 0.05. interestingly, phenotype A was shown high level of NRG4 following phenotype C than phenotype D and phenotype B. Receiver Operator Characteristic Curves (ROC) analysis for NRG4 was performed and showed good diagnostic performers to word phenotype A.

Conclusions: Females with phenotype A have a higher level of NRG4 than other phenotypes, which could be attributable to the more pronounced metabolic abnormalities in this phenotype.

多囊卵巢综合征 (PCOS) 表型中的神经胶质蛋白 4:关键作用或备用。
背景:Neuregulin_4(NRG4)是合成脂肪组织的脂肪因子成员之一。它对表皮生长因子受体(ErbB 受体)具有激活作用。NRG4 通过与 ErbB 受体相互作用,对激素环境产生间接影响。当多囊卵巢综合症患者的 NRG4 水平较高时,可能会出现胰岛素抵抗和慢性低度炎症。肥胖症和多囊卵巢综合症最近受到了广泛关注。然而,有关 NRG4 与多囊卵巢综合症表型之间联系的文献却很有限。因此,本研究旨在确定神经胶质蛋白4作为多囊卵巢综合征表型中胰岛素抵抗的生物标志物的功能:方法:病例对照研究,纳入 140 例不同表型多囊卵巢综合征的女性病例。患者样本在伊拉克卡尔巴拉卫生局妇产科教学医院生殖生育顾问处采集。门诊血清激素水平和胰岛素浓度由电化学发光免疫测定 "ECLIA "系统测定。Elisa 系统用于检测神经胶质蛋白-4 蛋白水平:有趣的是,与表型 D 和表型 B 相比,表型 A 在表型 C 之后显示出较高的 NRG4 水平。对 NRG4 进行了接收运算特性曲线(ROC)分析,结果显示表型 A 具有良好的诊断性能:结论:与其他表型相比,表型 A 女性的 NRG4 水平更高,这可能是因为该表型的代谢异常更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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