Vitamin D [Serum 25(OH) cholecalciferol] Insufficiency is Associated With Childhood Asthma: Recent Case-Control Findings From Bangladesh.

IF 1.4 Q3 PEDIATRICS

Global Pediatric Health Pub Date : 2024-04-03 eCollection Date: 2024-01-01 DOI:10.1177/2333794X241240574

Nabila Tabassum, Kazi Selim Anwar, Probir Kumar Sarkar, A R M Luthful Kabir, Md Abid Hossain Mollah, Dipa Saha, Md Jahangir Alam, Mohammod Jobayer Chisti

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Abstract

Objectives. To evaluate the interaction between childhood asthma and S. 25(OH) cholecalciferol among Bangladeshi children. Methods. This case control study was conducted in child asthma clinic, Bangladesh Shishu Hospital Institute during March-August 2021. Comparison was made between clinically-diagnosed (following GINA guideline) asthmatic children (2-12 years-old) (cases = 87) and age and sex-matched children having no respiratory illness (controls = 90) using SPSS' (Statistical Package for Social Science, V.23.0 Windows) software. Results. Serum 25(OH) cholecalciferol was found to be significantly lower among the cases than the controls (P < .01). The cases had 3.4 times higher likelihood of having low vitamin D (combined deficient + insufficient) than the controls (P < .01). Conclusions. The results of the study demonstrate an association of Serum 25 (OH) cholecalciferol with asthma which underscores the importance of potential future trial to evaluate the efficacy of Vitamin-D supplementation for understanding the outcomes of asthmatic Bangladeshi children.

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维生素 D [血清 25(OH) 胆钙化醇] 不足与儿童哮喘有关：孟加拉国的最新病例对照研究结果。

目的：评估孟加拉国儿童哮喘与 S. 25（OH）胆钙化醇之间的相互作用。评估孟加拉儿童哮喘与 S. 25（OH）胆钙化醇之间的相互作用。方法。这项病例对照研究于 2021 年 3 月至 8 月期间在孟加拉国 Shishu 医院研究所的儿童哮喘诊所进行。使用 SPSS'（社会科学统计软件包，V.23.0 Windows）软件，对临床诊断（根据 GINA 指南）的哮喘儿童（2-12 岁）（病例 = 87）与年龄和性别匹配的无呼吸道疾病儿童（对照 = 90）进行比较。结果发现病例的血清 25（OH）胆钙化醇明显低于对照组（P P 结论：研究结果表明，病例的血清 25（OH）胆钙化醇与呼吸道疾病有关。研究结果表明，血清 25（OH）胆钙化醇与哮喘有关，这凸显了未来潜在试验的重要性，即评估维生素 D 补充剂的功效，以了解孟加拉哮喘儿童的预后。

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