Combined Effects of Early Life Stress and Prolonged Exposure to Western Diet on Emotional Responses and Gut Microbiota.

IF 3.2 2区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY
Isabel López-Taboada, Silvia Arboleya, Saúl Sal-Sarria, Miguel Gueimonde, Héctor González-Pardo, Nélida M Conejo
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引用次数: 0

Abstract

Background: Exposure to early life stress (ELS) and maternal consumption of a high-fat and high-sugar diet can have detrimental effects on adult emotional responses. The microbiota and gut-brain axis have been proposed as playing a mediating role in the regulation of stress and emotion.

Method: Young male rats were exposed to maternal separation (MS) together with maternal and postnatal consumption of a HFS diet (45%kcal saturated fat, 17%kcal sucrose). Anxiety-like behaviour was evaluated using an elevated zero-maze, and depression-like behaviour using the forced-swim and sucrose preference tests. Microbiota composition and derived metabolites were also analysed in faecal samples using a gas chromatograph and mass spectrometry.

Results: Combined exposure to MS and lifelong consumption of a HFS diet partially reversed the abnormal anxiety-like and depression-like behaviours in early adulthood caused by each adverse factor alone. Diet composition had a greater negative impact than ELS exposure on the gut microbiota, and both environmental factors interacted with microbiota composition partially counteracting their negative effects.

Conclusions: The effects of exposure to early life stress and a HFS diet independently are partially reversed after the combination of both factors. These results suggest that ELS and diet interact to modulate adult stress response and gut microbiota.

早期生活压力和长期接触西方饮食对情绪反应和肠道微生物群的综合影响
背景:早期生活压力(ELS)和母体摄入高脂高糖饮食会对成年后的情绪反应产生不利影响。微生物群和肠道-大脑轴被认为在压力和情绪的调节中起着中介作用:方法:将幼年雄性大鼠置于母体分离(MS)以及母体和产后摄入高糖饮食(45% 千卡饱和脂肪、17% 千卡蔗糖)的环境中。焦虑样行为通过高架零迷宫进行评估,抑郁样行为通过强迫游泳和蔗糖偏好测试进行评估。还使用气相色谱仪和质谱仪分析了粪便样本中的微生物群组成和衍生代谢物:结果:将暴露于 MS 和终生食用 HFS 饮食结合起来,可部分逆转成年早期由每个不利因素单独引起的异常焦虑样和抑郁样行为。膳食组成对肠道微生物群的负面影响大于暴露于ELS的影响,这两种环境因素与微生物群组成相互作用,部分抵消了它们的负面影响:结论:早期生活压力暴露和高脂饮食的影响在这两种因素共同作用下被部分逆转。这些结果表明,早期生命应激反应和饮食会相互作用,调节成年后的应激反应和肠道微生物群。
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来源期刊
Psicothema
Psicothema PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
6.50
自引率
16.70%
发文量
69
审稿时长
24 weeks
期刊介绍: La revista Psicothema fue fundada en Asturias en 1989 y está editada conjuntamente por la Facultad y el Departamento de Psicología de la Universidad de Oviedo y el Colegio Oficial de Psicólogos del Principado de Asturias. Publica cuatro números al año. Se admiten trabajos tanto de investigación básica como aplicada, pertenecientes a cualquier ámbito de la Psicología, que previamente a su publicación son evaluados anónimamente por revisores externos. Psicothema está incluida en las bases de datos nacionales e internacionales más relevantes, entre las que cabe destacar Psychological Abstracts, Current Contents y MEDLINE/Index Medicus, entre otras. Además, figura en las listas de Factor de Impacto del Journal Citation Reports. Psicothema es una revista abierta a cualquier enfoque u orientación psicológica que venga avalada por la fuerza de los datos y los argumentos, y en la que encuentran acomodo todos los autores que sean capaces de convencer a los revisores de que sus manuscritos tienen la calidad para ser publicados. Psicothema es una revista de acceso abierto lo que significa que todo el contenido está a disposición de cualquier usuario o institución sin cargo alguno. Los usuarios pueden leer, descargar, copiar, distribuir, imprimir, buscar, o realizar enlaces a los textos completos de esta revista sin pedir permiso previo al editor o al autor, siempre y cuando la fuente original sea referenciada. Para acervos y repositorios, se prefiere que la cobertura se realice mediante enlaces a la propia web de Psicothema. Nos parece que una apuesta decidida por la calidad es el mejor modo de servir a nuestros lectores, cuyas sugerencias siempre serán bienvenidas.
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