Association between colonic adenoma size and proliferative zone in the crypt.

IF 1.6 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Scandinavian Journal of Gastroenterology Pub Date : 2024-07-01 Epub Date: 2024-05-03 DOI:10.1080/00365521.2024.2345385

Toshihiro Nishizawa, Hidenobu Watanabe, Shuntaro Yoshida, Tatsuya Matsuno, Ai Fujimoto, Rie Matsuda, Hirotoshi Ebinuma, Mitsuhiro Fujishiro, Yutaka Saito, Osamu Toyoshima

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引用次数: 0

Abstract

Background: We previously reported unusual adenomas with proliferative zones confined to the lower two-thirds of the crypt. The proliferative zones of colorectal adenomas have three patterns: 'lower,' 'superficial' and 'entire'. This study aimed to clarify the characteristics of each adenoma pattern.

Methods: We investigated 2925 consecutive patients who underwent colonoscopy at our institute. All polyps that were removed were histologically examined using hematoxylin and eosin staining. The location of the proliferative zone was assessed for adenomas. Data were compared using Dunn's and Kruskal-Wallis tests.

Results: Colorectal adenomas with 'lower' proliferative zone often appeared similar to hyperplastic polyps (42.8%), and the frequency was significantly higher than that of adenomas with 'superficial' and 'entire' proliferative zones (p < 0.001). The mean sizes of adenomas were 2.4, 3.0 and 3.9 mm for 'lower,' 'superficial' and 'entire' proliferative zones, respectively. A significant gradual increase was observed. Regarding morphology, the proportion of type 0-I in adenomas with an 'entire' proliferative zone was significantly higher than that in adenomas with 'superficial' proliferative zone (p < 0.001).

Conclusion: While colorectal adenomas develop and increase in size, the proliferative zone appears to shift upward and become scattered.

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结肠腺瘤大小与隐窝增殖区之间的关系

背景：我们曾报道过不常见的腺瘤，其增殖区仅限于隐窝的下三分之二。大肠腺瘤的增殖区有三种模式：下部"、"表层 "和 "整个"。本研究旨在阐明每种腺瘤模式的特征：我们调查了在我院接受结肠镜检查的 2925 名连续患者。所有切除的息肉均采用苏木精和伊红染色进行组织学检查。对腺瘤的增殖区位置进行了评估。数据比较采用 Dunn's 检验和 Kruskal-Wallis 检验：结果：具有 "较低 "增殖区的大肠腺瘤通常与增生性息肉相似（42.8%），其发生率明显高于具有 "较浅 "和 "整个 "增殖区的腺瘤（P P 结论：虽然大肠腺瘤具有 "较低 "增殖区，但其发生率明显高于增生性息肉（42.8%）：大肠腺瘤在发展和增大的同时，增生区似乎会上移并变得分散。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

3.40

自引率

5.30%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The Scandinavian Journal of Gastroenterology is one of the most important journals for international medical research in gastroenterology and hepatology with international contributors, Editorial Board, and distribution