Quantitative Autofluorescence at AMD's Beginnings Highlights Retinal Topography and Grading System Differences: ALSTAR2 Baseline.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Ophthalmologica Pub Date : 2024-04-24 DOI:10.1159/000538696

Andreas Berlin, Nathan A Fischer, Mark E Clark, Deepayan Kar, Thomas A Swain, Richard M Martindale, Gerald McGwin, Jason N Crosson, Kenneth R Sloan, Cynthia Owsley, Christine A Curcio

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引用次数: 0

Abstract

Introduction: The aims of the study were to describe baseline quantitative (short-wavelength) autofluorescence (qAF) findings in a large pseudophakic cohort at age-related macular degeneration (AMD)'s beginnings and to assess qAF8 as an outcome measure and evaluate Age-Related Eye Disease Study (AREDS) and Beckman grading systems.

Methods: In the ALSTAR2 baseline cohort (NCT04112667), 346 pseudophakic eyes of 188 persons (74.0 ± 5.5 years) were classified as normal (N = 160 by AREDS, 158 by Beckman), early AMD (eAMD) (N = 104, 66), and intermediate AMD (iAMD) (N = 82, 122). Groups were compared via mean qAF intensities in a 6°-8° annulus (qAF8) and maps of differences between observations and the overall mean, divided by standard deviation (Z-score).

Results: qAF8 did not differ significantly among diagnostic groups by either stratification (p = 0.0869 AREDS; p = 0.0569 by Beckman). Notably, 45 eyes considered eAMD by AREDS became iAMD by Beckman. For AREDS-stratified eyes, Z-score maps showed higher centrally located qAF for normal, near the mean in eAMD, and lower values for iAMD. Maps deviated from this pattern for Beckman-stratified eyes.

Conclusions: In a large sample of pseudophakic eyes, qAF8 does not differ overall from normal aging to iAMD but also does not capture the earliest AMD activity in the macula lutea. AREDS classification gives results more consistent with a slow decline in histologic autofluorescence than Beckman classification.

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AMD 初期的定量自发荧光可突出显示视网膜地形图和分级系统的差异：ALSTAR2 基线。

目的：描述年龄相关性黄斑变性（AMD）初期大型假性角膜队列中的基线定量（短波长）自发荧光（qAF）结果；将qAF8作为结果测量指标进行评估，并对AREDS和贝克曼分级系统进行评价：在ALSTAR2基线队列（NCT04112667）中，188人（74.0 ± 5.5岁）的346只假视网膜眼被分为正常（AREDS为160只，Beckman为158只）、早期（e）AMD（104只，66只）和中期（i）AMD（82只，122只）。通过 6°- 8° 环面的平均 qAF 强度（qAF8）和观察值与总平均值之间的差异图（除以标准偏差（Z-score））对各组进行比较。结果：在两种分层方法中，qAF8 在诊断组之间均无显著差异（AREDS 方法中 p = 0.0869；Beckman 方法中 p = 0.0569）。值得注意的是，有 45 只被 AREDS 诊断为 eAMD 的眼睛被 Beckman 诊断为 iAMD。对于 AREDS 分层眼，Z-score 地图显示正常眼的 qAF 中心位置较高，接近 eAMD 的平均值，而 iAMD 的 qAF 值较低。贝克曼分层眼的地图偏离了这一模式：在大量假性视网膜眼样本中，qAF8 从整体上看与正常老化到 iAMD 没有差异，但也不能捕捉到黄斑中最早的 AMD 活动。与贝克曼分类法相比，AREDS分类法得出的结果更符合组织学自发荧光的缓慢衰退。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.