Predictive Value of Serum microRNA-29b-3p in Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation

IF 3.6 3区医学

Clinical Interventions in Aging Pub Date : 2024-05-03 DOI:10.2147/cia.s450292

Junwei Zhan, Chengfei Peng, Yuxin Liu, Zhanhua Bi, Guoxiu Lu, Shanhu Hao, Yanan Tong, Guoxu Zhang

{"title":"Predictive Value of Serum microRNA-29b-3p in Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation","authors":"Junwei Zhan, Chengfei Peng, Yuxin Liu, Zhanhua Bi, Guoxiu Lu, Shanhu Hao, Yanan Tong, Guoxu Zhang","doi":"10.2147/cia.s450292","DOIUrl":null,"url":null,"abstract":"Objective: Atrial fibrillation (AF) is a common arrhythmia. This study explored serum miR-29b-3p expression in AF patients and its value in predicting AF recurrence after radiofrequency catheter ablation (RFCA). Methods: Totally 100 AF patients who underwent RFCA were enrolled, with 100 individuals without AF as controls. Serum miR-29b-3p expression in participants was determined using RT-qPCR. The correlation between miR-29b-3p and atrial fibrosis markers (FGF-21/FGF-23) was assessed by Pearson analysis. The diagnostic efficacy of serum miR-29b-3p and FGF-21/FGF-23 in predicting AF recurrence after RFCA was analyzed by the receiver operating characteristic (ROC) curves. The Kaplan-Meier method was adopted to evaluate the effect of miR-29b-3p expression on the incidence of AF recurrence after RFCA. The independent risk factors for AF recurrence after RFCA were analyzed by logistic regression analysis. Results: Serum miR-29b-3p was poorly expressed in AF patients. After RFCA, AF patients showed elevated serum miR-29b-3p expression. Serum miR-29b-3p expression in AF patients negatively correlated with serum FGF-21 and FGF-23 concentrations. The cut-off values of serum miR-29b-3p, FGF-21, and FGF-23 in identifying AF recurrence were 0.860 (sensitivity: 100.00%, specificity: 39.71%), 222.2 pg/mL (sensitivity: 96.88%, specificity: 32.35%) and 216.3 ng/mL (sensitivity: 53.13%, specificity: 70.59%), respectively. Patients with low miR-29b-3p expression had a significantly higher incidence of AF recurrence than patients with high miR-29b-3p expression. Serum miR-29b-3p expression was one of the independent risk factors for AF recurrence after RFCA. Conclusion: Low miR-29b-3p expression in AF patients has certain predictive values and is one of the independent risk factors for AF recurrence after RFCA. Keywords: miR-29b-3p, atrial fibrillation, radiofrequency catheter ablation, recurrence, fibrosis marker, logistic regression analysis ","PeriodicalId":10417,"journal":{"name":"Clinical Interventions in Aging","volume":"32 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Interventions in Aging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/cia.s450292","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Atrial fibrillation (AF) is a common arrhythmia. This study explored serum miR-29b-3p expression in AF patients and its value in predicting AF recurrence after radiofrequency catheter ablation (RFCA).
Methods: Totally 100 AF patients who underwent RFCA were enrolled, with 100 individuals without AF as controls. Serum miR-29b-3p expression in participants was determined using RT-qPCR. The correlation between miR-29b-3p and atrial fibrosis markers (FGF-21/FGF-23) was assessed by Pearson analysis. The diagnostic efficacy of serum miR-29b-3p and FGF-21/FGF-23 in predicting AF recurrence after RFCA was analyzed by the receiver operating characteristic (ROC) curves. The Kaplan-Meier method was adopted to evaluate the effect of miR-29b-3p expression on the incidence of AF recurrence after RFCA. The independent risk factors for AF recurrence after RFCA were analyzed by logistic regression analysis.
Results: Serum miR-29b-3p was poorly expressed in AF patients. After RFCA, AF patients showed elevated serum miR-29b-3p expression. Serum miR-29b-3p expression in AF patients negatively correlated with serum FGF-21 and FGF-23 concentrations. The cut-off values of serum miR-29b-3p, FGF-21, and FGF-23 in identifying AF recurrence were 0.860 (sensitivity: 100.00%, specificity: 39.71%), 222.2 pg/mL (sensitivity: 96.88%, specificity: 32.35%) and 216.3 ng/mL (sensitivity: 53.13%, specificity: 70.59%), respectively. Patients with low miR-29b-3p expression had a significantly higher incidence of AF recurrence than patients with high miR-29b-3p expression. Serum miR-29b-3p expression was one of the independent risk factors for AF recurrence after RFCA.
Conclusion: Low miR-29b-3p expression in AF patients has certain predictive values and is one of the independent risk factors for AF recurrence after RFCA.

Keywords: miR-29b-3p, atrial fibrillation, radiofrequency catheter ablation, recurrence, fibrosis marker, logistic regression analysis

查看原文本刊更多论文

血清 microRNA-29b-3p 对射频导管消融术后心房颤动复发的预测价值

目的：心房颤动（AF）是一种常见的心律失常。本研究探讨了房颤患者血清 miR-29b-3p 的表达及其在预测射频导管消融术（RFCA）后房颤复发方面的价值：方法：共招募了100名接受射频导管消融术的房颤患者，并以100名未接受射频导管消融术的患者作为对照。采用 RT-qPCR 方法测定参与者血清中 miR-29b-3p 的表达。通过皮尔逊分析评估了 miR-29b-3p 与心房纤维化标志物（FGF-21/FGF-23）之间的相关性。通过接收器操作特征曲线（ROC）分析了血清 miR-29b-3p 和 FGF-21/FGF-23 在预测 RFCA 后房颤复发方面的诊断效果。采用 Kaplan-Meier 法评估 miR-29b-3p 表达对 RFCA 后房颤复发率的影响。采用逻辑回归分析法分析了RFCA后房颤复发的独立危险因素：结果：心房颤动患者血清 miR-29b-3p 表达较低。RFCA后，房颤患者血清miR-29b-3p表达升高。房颤患者血清 miR-29b-3p 表达与血清 FGF-21 和 FGF-23 浓度呈负相关。血清 miR-29b-3p、FGF-21 和 FGF-23 识别房颤复发的临界值分别为 0.860（灵敏度：100.00%，特异性：39.71%）、222.2 pg/mL（灵敏度：96.88%，特异性：32.35%）和 216.3 ng/mL（灵敏度：53.13%，特异性：70.59%）。miR-29b-3p 低表达患者的房颤复发率明显高于 miR-29b-3p 高表达患者。血清 miR-29b-3p 表达是 RFCA 后房颤复发的独立风险因素之一：miR-29b-3p在房颤患者中的低表达具有一定的预测价值，是RFCA术后房颤复发的独立危险因素之一。关键词：miR-29b-3p；房颤；射频导管消融；复发；纤维化标志物；逻辑回归分析

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.