Blood miRNAs as Potential Diagnostic Biomarkers for Chronic Obstructive Pulmonary Disease: A Meta-Analysis

IF 2.8 3区医学 Q1 Medicine

International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-05-03 DOI:10.2147/copd.s457172

Xiaohua Li, Guoxia Fu, Chunrong Zhang, Yu Wu, Hua Guo, Weiming Li, Xuefeng Zeng

{"title":"Blood miRNAs as Potential Diagnostic Biomarkers for Chronic Obstructive Pulmonary Disease: A Meta-Analysis","authors":"Xiaohua Li, Guoxia Fu, Chunrong Zhang, Yu Wu, Hua Guo, Weiming Li, Xuefeng Zeng","doi":"10.2147/copd.s457172","DOIUrl":null,"url":null,"abstract":"Purpose: Investigate the efficacy of blood microRNAs (miRNAs) as diagnostic biomarkers for Chronic Obstructive Pulmonary Disease (COPD). Patients and Methods: We conducted a comprehensive search in English and Chinese databases, selecting studies based on predetermined criteria. Diagnostic parameters like summarized sensitivity (SSEN), summarized specificity (SSPE), summarized positive likelihood ratio (SPLR), summarized negative likelihood ratio (SNLR), and diagnostic odds ratio (DOR), and area under the curve (AUC) of the summary receiver operating characteristic (SROC) curves were analyzed using a bivariate model. Each parameter was accompanied by a 95% confidence interval (CI). Results: Eighteen high-quality studies were included. For diagnosing COPD with blood miRNAs, the SSEN was 0.83 (95% CI 0.76– 0.89), SSPE 0.76 (95% CI 0.70– 0.82), SPLR 3.50 (95% CI 2.66– 4.60), SNLR 0.22 (95% CI 0.15– 0.33), DOR 15.72 (95% CI 8.58– 28.77), and AUC 0.86 (95% CI 0.82– 0.88). In acute exacerbations, SSEN was 0.85 (95% CI 0.76– 0.91), SSPE 0.80 (95% CI 0.73– 0.86), SPLR 4.26 (95% CI 3.05– 5.95), SNLR 0.19 (95% CI 0.12– 0.30), DOR 22.29 (95% CI 11.47– 43.33), and AUC 0.89 (95% CI 0.86– 0.91). Conclusion: Blood miRNAs demonstrate significant accuracy in diagnosing COPD, both in general and during acute exacerbations, suggesting their potential as reliable biomarkers. Keywords: miRNAs, chronic obstructive pulmonary disease, biomarker, meta-analysis, diagnosis ","PeriodicalId":13792,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chronic Obstructive Pulmonary Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/copd.s457172","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Investigate the efficacy of blood microRNAs (miRNAs) as diagnostic biomarkers for Chronic Obstructive Pulmonary Disease (COPD).
Patients and Methods: We conducted a comprehensive search in English and Chinese databases, selecting studies based on predetermined criteria. Diagnostic parameters like summarized sensitivity (SSEN), summarized specificity (SSPE), summarized positive likelihood ratio (SPLR), summarized negative likelihood ratio (SNLR), and diagnostic odds ratio (DOR), and area under the curve (AUC) of the summary receiver operating characteristic (SROC) curves were analyzed using a bivariate model. Each parameter was accompanied by a 95% confidence interval (CI).
Results: Eighteen high-quality studies were included. For diagnosing COPD with blood miRNAs, the SSEN was 0.83 (95% CI 0.76– 0.89), SSPE 0.76 (95% CI 0.70– 0.82), SPLR 3.50 (95% CI 2.66– 4.60), SNLR 0.22 (95% CI 0.15– 0.33), DOR 15.72 (95% CI 8.58– 28.77), and AUC 0.86 (95% CI 0.82– 0.88). In acute exacerbations, SSEN was 0.85 (95% CI 0.76– 0.91), SSPE 0.80 (95% CI 0.73– 0.86), SPLR 4.26 (95% CI 3.05– 5.95), SNLR 0.19 (95% CI 0.12– 0.30), DOR 22.29 (95% CI 11.47– 43.33), and AUC 0.89 (95% CI 0.86– 0.91).
Conclusion: Blood miRNAs demonstrate significant accuracy in diagnosing COPD, both in general and during acute exacerbations, suggesting their potential as reliable biomarkers.

Keywords: miRNAs, chronic obstructive pulmonary disease, biomarker, meta-analysis, diagnosis

查看原文本刊更多论文

血液 miRNAs 作为慢性阻塞性肺病的潜在诊断生物标记物：一项元分析

目的：研究血液微RNA（miRNA）作为慢性阻塞性肺病（COPD）诊断生物标志物的有效性：我们在中英文数据库中进行了全面检索，根据预先确定的标准筛选研究。使用双变量模型分析了诊断参数，如概括灵敏度（SSEN）、概括特异度（SSPE）、概括阳性似然比（SPLR）、概括阴性似然比（SNLR）和诊断几率比（DOR），以及概括接收者操作特征曲线（SROC）的曲线下面积（AUC）。每个参数都附有 95% 的置信区间 (CI)：结果：共纳入了 18 项高质量的研究。用血液 miRNA 诊断慢性阻塞性肺病的 SSEN 为 0.83（95% CI 0.76-0.89），SSPE 为 0.76（95% CI 0.70-0.82），SPLR 为 3.50（95% CI 2.66-4.60），SNLR 为 0.22（95% CI 0.15-0.33），DOR 为 15.72（95% CI 8.58-28.77），AUC 为 0.86（95% CI 0.82-0.88）。在急性加重期，SSEN 为 0.85 (95% CI 0.76- 0.91)，SSPE 为 0.80 (95% CI 0.73- 0.86)，SPLR 为 4.26 (95% CI 3.05- 5.95)，SNLR 为 0.19 (95% CI 0.12- 0.30)，DOR 为 22.29 (95% CI 11.47- 43.33)，AUC 为 0.89 (95% CI 0.86- 0.91)：血液miRNAs在诊断慢性阻塞性肺疾病（包括一般情况和急性加重期）时表现出明显的准确性，表明它们具有作为可靠生物标志物的潜力。关键词：miRNAs；慢性阻塞性肺疾病；生物标志物；荟萃分析；诊断

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

5.10

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals

文献相关原料

公司名称	产品信息	采购帮参考价格