Campylobacter jejuni virulence factors: update on emerging issues and trends

IF 9 2区 医学 Q1 CELL BIOLOGY
Alexandra Tikhomirova, Emmylee R. McNabb, Luca Petterlin, Georgia L. Bellamy, Kyaw H. Lin, Christopher A. Santoso, Ella S. Daye, Fatimah M. Alhaddad, Kah Peng Lee, Anna Roujeinikova
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引用次数: 0

Abstract

Campylobacter jejuni is a very common cause of gastroenteritis, and is frequently transmitted to humans through contaminated food products or water. Importantly, C. jejuni infections have a range of short- and long-term sequelae such as irritable bowel syndrome and Guillain Barre syndrome. C. jejuni triggers disease by employing a range of molecular strategies which enable it to colonise the gut, invade the epithelium, persist intracellularly and avoid detection by the host immune response. The objective of this review is to explore and summarise recent advances in the understanding of the C. jejuni molecular factors involved in colonisation, invasion of cells, collective quorum sensing-mediated behaviours and persistence. Understanding the mechanisms that underpin the pathogenicity of C. jejuni will enable future development of effective preventative approaches and vaccines against this pathogen.
空肠弯曲菌毒力因子:新出现的问题和趋势的最新情况
空肠弯曲菌是肠胃炎的常见病因,经常通过受污染的食品或水传播给人类。重要的是,空肠弯曲菌感染会产生一系列短期和长期后遗症,如肠易激综合征和格林巴利综合征。空肠大肠杆菌通过采用一系列分子策略引发疾病,这些策略使空肠大肠杆菌能够在肠道中定植、侵入上皮细胞、在细胞内存活并避免被宿主免疫反应检测到。本综述旨在探讨和总结在了解空肠大肠杆菌定植、入侵细胞、集体法定量感应介导的行为和持续存在等分子因素方面的最新进展。了解空肠大肠杆菌致病性的基本机制将有助于未来针对这种病原体开发有效的预防方法和疫苗。
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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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