Neutron Activation Analysis Based on AB-BNCT Treatment Room.

IF 1 4区医学 Q4 ENVIRONMENTAL SCIENCES

Health physics Pub Date : 2024-04-26 DOI:10.1097/hp.0000000000001819

Yunzhu Cai, Shaoxian Gu, Ningyu Wang, Fengjie Cui, Wei Liu, Tianhang Li, Zhangwen Wu, Chengjun Gou

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引用次数: 0

Abstract

Boron neutron capture therapy (BNCT) is an ideal binary targeted radiotherapy for treating refractory tumors. An accelerator-based BNCT (AB-BNCT) neutron source has attracted more and more attention due to its advantages such as higher neutron yield in the keV energy region, less gamma radiation, and higher safety. In addition to 10B, neutrons also react with other elements in the treatment room during BNCT to produce many activation products. Due to the long half-life of some activation products, there will be residual radiation after the end of treatment and the shutdown of the accelerator, which has adverse effects on radiation workers. Therefore, the ambient dose equivalent rate in the treatment room needs to be evaluated. The AB-BNCT neutron source model proposed by Li is studied in this paper. Based on the Monte Carlo method, the Geant4 platform was used to simulate the dose induced by radionuclides near the Beam Shaping Assembly (BSA) of the source. It is concluded that the concrete wall contributed the most to the radiation dose. The dose rate of 2.45 μSv h-1 after 13 min of shutdown meets the dose rate limit of 2.5 μSv h-1, at which point it is safe for workers to enter the treatment room area.

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基于 AB-BNCT 治疗室的中子活化分析。

硼中子俘获疗法（BNCT）是治疗难治性肿瘤的理想二元靶向放射疗法。基于加速器的硼中子俘获疗法（AB-BNCT）中子源因其在keV能量区具有较高的中子产率、较少的伽马辐射和较高的安全性等优点而受到越来越多的关注。除 10B 外，中子还会在 BNCT 期间与治疗室内的其他元素发生反应，产生许多活化产物。由于一些活化产物的半衰期较长，在治疗结束、加速器关闭后会有残余辐射，对辐射工作人员产生不利影响。因此，需要对治疗室的环境剂量当量率进行评估。本文研究了 Li 提出的 AB-BNCT 中子源模型。基于蒙特卡洛方法，利用 Geant4 平台模拟了放射源光束整形组件（BSA）附近放射性核素引起的剂量。结果表明，混凝土墙对辐射剂量的影响最大。关闭 13 分钟后的剂量率为 2.45 μSv h-1，符合剂量率限值 2.5 μSv h-1，此时工人进入治疗室区域是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health physics 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

0.00%

发文量

324

审稿时长

3-8 weeks

期刊介绍： Health Physics, first published in 1958, provides the latest research to a wide variety of radiation safety professionals including health physicists, nuclear chemists, medical physicists, and radiation safety officers with interests in nuclear and radiation science. The Journal allows professionals in these and other disciplines in science and engineering to stay on the cutting edge of scientific and technological advances in the field of radiation safety. The Journal publishes original papers, technical notes, articles on advances in practical applications, editorials, and correspondence. Journal articles report on the latest findings in theoretical, practical, and applied disciplines of epidemiology and radiation effects, radiation biology and radiation science, radiation ecology, and related fields.