Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men.

IF 2.9 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Clinical Psychopharmacology Pub Date : 2024-04-29 DOI:10.1097/jcp.0000000000001849

Jonathan Covault, Howard Tennen, Richard Feinn

引用次数: 0

Abstract

Prior studies indicate that neuroactive steroids mediate some of alcohol's effects. Dutasteride, widely used to treat benign prostatic hypertrophy, is an inhibitor of 5-alpha reductase enzymes, which play a central role in the production of 5α-reduced neuroactive steroids. The purpose of this study was to test dutasteride's tolerability and efficacy for reducing drinking.

查看原文本刊更多论文

减少男性大量饮酒的度他雄胺随机安慰剂对照临床试验。

先前的研究表明，神经活性类固醇介导了酒精的某些作用。被广泛用于治疗良性前列腺肥大的度他雄胺是5-α还原酶的抑制剂，而5-α还原酶在产生5α还原型神经活性类固醇的过程中起着核心作用。本研究旨在测试度他雄胺对减少饮酒的耐受性和疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Psychopharmacology 医学-精神病学

CiteScore

4.00

自引率

3.40%

发文量

231

审稿时长

4-8 weeks

期刊介绍： Journal of Clinical Psychopharmacology, a leading publication in psychopharmacology, offers a wide range of articles reporting on clinical trials and studies, side effects, drug interactions, overdose management, pharmacogenetics, pharmacokinetics, and psychiatric effects of non-psychiatric drugs. The journal keeps clinician-scientists and trainees up-to-date on the latest clinical developments in psychopharmacologic agents, presenting the extensive coverage needed to keep up with every development in this fast-growing field.