Involvement of somatotrophic hormones in the postpartum regulation of ovarian activity in mares

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Maria Melchert , Jörg Aurich , Reinhard Ertl , Ursula Reichart , Ingrid Walter , Camille Gautier , Martim Kaps , Christine Aurich
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Abstract

Mares resume ovarian activity rapidly after foaling. Besides follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the pituitary synthesizes prolactin and growth hormone which stimulate insulin-like growth factor (IGF) synthesis in the liver. We tested the hypothesis that follicular growth is initiated already antepartum, mares with early and delayed ovulation differ in IGF-1 release and that there is an additional IGF-1 synthesis in the placenta. Plasma concentrations of LH, FSH, IGF-1, IGF-2, activin and prolactin. IGF-1, IGF-2, prolactin and their receptors in placental tissues were analyzed at the mRNA and protein level. Follicular growth was determined from 15 days before to 15 days after foaling in 14 pregnancies. Mares ovulating within 15 days postpartum formed group OV (n=5) and mares not ovulating within 15 days group NOV (n=9). Before foaling, follicles with a diameter >1 cm were present in all mares and their number increased over time (p<0.05). Follicle growth after foaling was more pronounced in OV mares (day p<0.001, group p<0.05, day x group p<0.05) in parallel to an increase in LH concentration (p<0.001, day x group p<0.001) while FSH increased (p<0.001) similarly in both groups. Plasma concentrations of IGF-1 and prolactin peaked one day after foaling (p<0.001). The IGF-1 mRNA abundance was higher in the allantochorion but lower in the amnion of OV versus NOV mares (group p=0.01, localization x group p<0.01). The IGF-1 receptor mRNA was most abundant in the allantochorion (p<0.001) and IGF-1 protein was expressed in placental tissue without differences between groups. In conclusion, follicular growth in mares is initiated before foaling and placental IGF-1 may enhance resumption of ovulatory cycles.

Abstract Image

瘤胃激素参与产后母马卵巢活动的调节
母马产驹后卵巢会迅速恢复活动。除了卵泡刺激素(FSH)和黄体生成素(LH)外,垂体还合成催乳素和生长激素,刺激肝脏合成胰岛素样生长因子(IGF)。我们对以下假设进行了测试:卵泡的生长在产前就已开始,排卵提前和推迟的母马在 IGF-1 的释放上存在差异,胎盘中存在额外的 IGF-1 合成。血浆中 LH、FSH、IGF-1、IGF-2、激活素和催乳素的浓度。对胎盘组织中的 IGF-1、IGF-2、催乳素及其受体的 mRNA 和蛋白质水平进行了分析。在 14 次妊娠中,测定了产前 15 天到产后 15 天的卵泡生长情况。产后15天内排卵的母马组成OV组(n=5),15天内不排卵的母马组成NOV组(n=9)。产驹前,所有母马都有直径为>1厘米的卵泡,其数量随着时间的推移而增加(p<0.05)。产后卵泡的增长在 OV 母马中更为明显(天 p<0.001,组 p<0.05,天 x 组 p<0.05),同时 LH 浓度也在增加(p<0.001,天 x 组 p<0.001),而 FSH 在两组中的增加(p<0.001)情况类似。IGF-1 和催乳素的血浆浓度在产后一天达到峰值(p<0.001)。与 NOV 母马相比,OV 母马尿囊中的 IGF-1 mRNA 丰度较高,但羊膜中的 IGF-1 mRNA 丰度较低(组 p=0.01,定位 x 组 p<0.01)。IGF-1 受体 mRNA 在尿囊最丰富(p<0.001),IGF-1 蛋白在胎盘组织中表达,组间无差异。总之,母马的卵泡生长是在产前开始的,胎盘 IGF-1 可促进排卵周期的恢复。
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来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
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