Michael addition reaction in C-5 of Camptothecin

IF 5.8 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Saudi Chemical Society Pub Date : 2024-05-01 DOI:10.1016/j.jscs.2024.101867

Changkuo Zhao , Linming Zuo , Xi Ke , Xianheng Wang

引用次数: 0

Abstract

A simple method for Michael addition at C-5 of Camptothecin has been developed to construct 5-CPT derivatives. The addition products were obtained with moderate yields, and the structures of the target compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS spectra. The feasibility of various Michael addition acceptors for this reaction has also been investigated.

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喜树碱 C-5 中的迈克尔加成反应

我们开发了一种在喜树碱的 C-5 位进行迈克尔加成的简单方法来构建 5-CPT 衍生物。通过 1H NMR、13C NMR 和 HRMS 光谱鉴定了目标化合物的结构。此外，还研究了各种迈克尔加成受体在该反应中的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Saudi Chemical Society CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

8.90

自引率

1.80%

发文量

120

审稿时长

38 days

期刊介绍： Journal of Saudi Chemical Society is an English language, peer-reviewed scholarly publication in the area of chemistry. Journal of Saudi Chemical Society publishes original papers, reviews and short reports on, but not limited to: •Inorganic chemistry •Physical chemistry •Organic chemistry •Analytical chemistry Journal of Saudi Chemical Society is the official publication of the Saudi Chemical Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.