A single-cell atlas of sex differences and androgen effects

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2024-05-03 DOI:10.1038/s41684-024-01368-5

Alexandra Le Bras

引用次数: 0

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性别差异和雄激素效应的单细胞图谱

激素，尤其是雄激素和雌激素，很可能是造成性别表型的主要原因。为了探索小鼠的性别差异以及雄激素在细胞和分子水平上对这些差异的调节作用，研究人员利用四组不同的小鼠对麝香猫（C57BL/6小鼠）的17种组织进行了单细胞转录组分析，这四组小鼠分别是：接受阉割的雄性小鼠、接受假手术的雄性小鼠、通过持续释放双氢睾酮（DHT）补充雄激素的雌性小鼠以及接受假手术的雌性小鼠。通过比较不同组别之间的数据，研究人员确定了受雄激素调控并可能驱动人类性别表型的基本性别偏见分子和细胞类型。研究小组还开发了一个计算管道，用于剖析雄激素-雄激素受体轴对小鼠的影响。结果可在这里找到：https://casadbtools.com/andr_effectOriginal 参考文献：Li, F. et al. Nature (2024) https://doi.org/10.1038/s41586-024-07291-6

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.