Cryo-EM structure reveals how SID-1 recognizes dsRNA that initiates systemic RNAi

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-03 DOI:10.1038/s41594-024-01277-8

引用次数: 0

Abstract

Systemic RNA interference (RNAi) in Caenorhabditis elegans is initiated by SID-1-mediated double-stranded RNA (dsRNA) internalization. By combining cryo-electron microscopy (cryo-EM), in vitro and in vivo assays, we show how SID-1 specifically recognizes dsRNA and provide important insights into dsRNA internalization by SID-1.

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低温电子显微镜结构揭示了 SID-1 如何识别启动系统性 RNAi 的 dsRNA

草履虫的系统 RNA 干扰（RNAi）是由 SID-1 介导的双链 RNA（dsRNA）内化启动的。通过结合低温电子显微镜（cryo-EM）、体外和体内试验，我们展示了 SID-1 如何特异性识别 dsRNA，并对 SID-1 内化 dsRNA 提供了重要见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.