Actin pushes open a leaky lumen

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-05-02 DOI:10.1016/j.stem.2024.04.003

Jia Guo, Yue Shao

引用次数: 0

Abstract

Using a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al.¹ establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.

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肌动蛋白推开泄漏的管腔

Indana 等人1 利用基于人类干细胞的模型来了解人类上胚层在植入初期是如何形成的，他们确定了由顶端肌动蛋白聚合产生的推力的作用，并揭示了上胚层空腔形态发生所依赖的两阶段生物力学驱动的腔体生长过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.