Sox9-coordinated cellular neighborhoods generate fibrosis

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-05-02 DOI:10.1016/j.stem.2024.04.009

Darrian Bugg, Jennifer Davis

引用次数: 0

Abstract

Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.

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Sox9 协调的细胞邻域产生纤维化

再生能力差的器官会沉积瘢痕组织以修补损伤。Aggarwal 等人证实，瞬时 Sox9 活性是早期近端小管上皮再生的必要条件，而 Trogisch 等人和 Aggarwal 等人的研究则表明，上皮细胞和内皮细胞中持续的 Sox9 活性会激活成纤维细胞，在多个器官中形成纤维化微域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.