Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In Silico Analyses

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2024-04-27 DOI:10.2174/0113816128283420240409050754

Myltykbay S. Rysmakhanov, Afshin Zare, Aibolat S. Smagulov, Nurgul A. Abenova, Nadiar M. Mussin, Yerlan B. Sultangereyev, Bazylbek S. Zhakiyev, Gani K. Kuttymuratov, Mehmet Haberal, Nazanin Jafari, Hanieh Baneshi, Shabnam Bakhshalizadeh, Mahdi Mahdipour, Farhad Rahmanifar, Amin Tamadon

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引用次数: 0

Abstract

Background: Ischemia-Reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion. Aim: This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI. Methods: Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-Like Receptor 4 (TLR4). This finding indicates eplerenone's potential as a potent preventive agent against IRI, surpassing other available therapeutics like Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. In preventing kidney IRI, our comprehensive analysis emphasizes the significance of eplerenone due to its strong binding affinity to key targets involved in the pathogenesis of IRI. Results: This finding positions eplerenone as a promising candidate for further clinical investigation and consideration for future clinical practice. Conclusion: The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.

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预防肾缺血再灌注损伤的创新策略综述：文献计量学和硅学分析的启示

背景：缺血再灌注损伤（IRI）是一个复杂的病理生理过程，具有严重的后果，包括不可逆转的肾功能丧失。人们提出了各种术中预防方法，以减轻温缺血和肾脏再灌注的有害影响。目的：这篇综合分析概述了预防和治疗肾脏 IRI 的药理药物和术中方法。方法：我们的分析表明，依普利酮与关键靶点的结合亲和力最高，这些靶点包括醛脱氢酶（AD）、雌激素受体（ER）、Klotho蛋白、矿质皮质激素受体（MR）和Toll-Like受体4（TLR4）。这一发现表明，依普利酮是一种有效的IRI预防剂，其潜力超过了苯并二氧戊环、氢化可的松、吲哚、烟酰胺腺嘌呤二核苷酸和烟酰胺等其他现有疗法。在预防肾脏 IRI 方面，我们的综合分析强调了依普利酮的重要性，因为它与 IRI 发病机制中的关键靶点有很强的结合亲和力。结果：这一发现将依普利酮定位为有希望进行进一步临床研究并在未来临床实践中加以考虑的候选药物。结论本分析提供的见解将有助于临床医生和研究人员在手术环境中选择有效的肾脏 IRI 预防方法，从而改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.