Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus

IF 2 4区 数学 Q2 BIOLOGY
Vladimira Suvandjieva, Ivanka Tsacheva, Marlene Santos, Georgios Kararigas, Peter Rashkov
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Abstract

The development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil’s nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the development of autoimmunogenicity in SLE. The aim of this work is to study how NETosis contributes to the establishment of persistent autoantigen production by analysing the steady states and the asymptotic dynamics of the model by numerical experiment.

Abstract Image

系统性红斑狼疮初期NETosis的影响建模
自身免疫性疾病的发展往往需要数年时间才能发现临床症状。我们提出了一个系统性红斑狼疮初期免疫反应的数学模型,该模型模拟了巨噬细胞和中性粒细胞的异常凋亡和活化过程。NETosis是一种细胞死亡类型,其特点是中性粒细胞胞外捕获物或NETs在病原体刺激下释放,其中含有来自中性粒细胞细胞核的物质。据推测,这一过程有助于系统性红斑狼疮自身免疫原性的发展。这项工作的目的是通过数值实验分析模型的稳态和渐近动态,研究NETosis如何促成持续性自身抗原的产生。
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来源期刊
CiteScore
3.90
自引率
8.60%
发文量
123
审稿时长
7.5 months
期刊介绍: The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including: Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations Research in mathematical biology education Reviews Commentaries Perspectives, and contributions that discuss issues important to the profession All contributions are peer-reviewed.
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