Isolation of 24-homoscalarane sesterterpenoids from a sponge of the genus Lendenfeldia

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-04-27 DOI:10.1016/j.phytol.2024.04.013

Li-Guo Zheng , You-Yan Chen , Chia-Ching Liaw , Yu-Chi Lin , Su-Ying Chien , Yi-Hao Lo , Yu-Chi Tsai , Hao-Chun Hu , You-Ying Chen , Tsong-Long Hwang , Tzu-Ming Ou , Ping-Jyun Sung

引用次数: 0

Abstract

The chemical screening of an algae-containing marine sponge identified as Lendenfeldia species has isolated two 24-homoscalarane sesterterpenoids, including a known compound, felixin A (1) and a new analogue, lendenfeldarane V (2). The structure of 1, obtained in a previous study, was cited for the first time in this study via single-crystal X-ray diffraction analysis. The structure of 2 was ascertained via 2D NMR experiments and a literature review. The absolute configurations of 1 and 2 were delineated with DP4+ computation and specific optical rotation. Homoscalarane 1 exhibited cytotoxicity towards MG63 human osteosarcoma cells.

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从 Lendenfeldia 属海绵中分离出 24-homoscalarane 酯类化合物

通过对一种被鉴定为 Lendenfeldia 物种的含藻海洋海绵进行化学筛选，分离出了两种 24-homoscalarane 酯类化合物，包括一种已知化合物 felixin A（1）和一种新的类似物 lendenfeldarane V（2）。通过单晶 X 射线衍射分析，本研究首次引用了之前研究中获得的 1 的结构。2 的结构是通过二维核磁共振实验和文献综述确定的。通过 DP4+ 计算和特定光学旋转，划定了 1 和 2 的绝对构型。Homoscalarane 1 对 MG63 人类骨肉瘤细胞具有细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.