Dronedarone Attenuates Ang II-Induced Myocardial Hypertrophy Through Regulating SIRT1/FOXO3/PKIA Axis.

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Korean Circulation Journal Pub Date : 2024-04-24 DOI:10.4070/kcj.2023.0197

Cheng Chen, Song Hu, Heng-Jing Hu, Zhi-Xuan Liu, Xin-Teng Wu, Tao Zou, Hua Su

引用次数: 0

Abstract

Long-term pathological myocardial hypertrophy (MH) seriously affects the normal function of the heart. Dronedarone was reported to attenuate left ventricular hypertrophy of mice. However, the molecular regulatory mechanism of dronedarone in MH is unclear.

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决奈达隆通过调节 SIRT1/FOXO3/PKIA 轴减轻 Ang II 诱导的心肌肥厚

长期病理性心肌肥厚（MH）严重影响心脏的正常功能。据报道，决奈达隆可减轻小鼠左心室肥厚。然而，决奈达隆在MH中的分子调控机制尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Circulation Journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

17.20%

发文量

103

期刊介绍： Korean Circulation Journal is the official journal of the Korean Society of Cardiology, the Korean Pediatric Heart Society, the Korean Society of Interventional Cardiology, and the Korean Society of Heart Failure. Abbreviated title is ''Korean Circ J''. Korean Circulation Journal, established in 1971, is a professional, peer-reviewed journal covering all aspects of cardiovascular medicine, including original articles of basic research and clinical findings, review articles, editorials, images in cardiovascular medicine, and letters to the editor. Korean Circulation Journal is published monthly in English and publishes scientific and state-of-the-art clinical articles aimed at improving human health in general and contributing to the treatment and prevention of cardiovascular diseases in particular. The journal is published on the official website (https://e-kcj.org). It is indexed in PubMed, PubMed Central, Science Citation Index Expanded (SCIE, Web of Science), Scopus, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, KoreaMed, KoreaMed Synapse and KoMCI, and easily available to wide international researchers