Preparation, Characterization, and Biological Activity of La(III), Nd(III), Er(III), Gd(III), and Dy(III) Complexes with Schiff Base Resulted from Reaction of 4-Antipyrinecarboxaldehyde and 2-Aminobenzothiazole

IF 1 Q4 CHEMISTRY, MULTIDISCIPLINARY

Indonesian Journal of Chemistry Pub Date : 2024-04-01 DOI:10.22146/ijc.87262

Kawther Adeeb Hussein, Naser Shaalan, Aliaa Khauon Lafta, Janan Majeed Al Akeedi

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Abstract

The research includes the preparation of several complexes of the internal transition elements lanthanide (Ln = La, Nd, Er, Gd, and Dy) containing the 4f shell, with Schiff bases resulting from condensation reactions between 4-antipyrinecarboxaldehyde and 2-aminobenzothiazoles. Schiff's base was identified using FTIR spectra, UV-vis spectroscopy, elemental microanalysis CHNSO, nuclear magnetic resonance, mass spectrometry, and TGA thermal analysis. The complexes were studied and identified with elemental microanalysis CHNSO, FTIR spectroscopy, UV-vis spectroscopy, TGA thermal analysis, conductivity measurement, and magnetic sensitivity. The result showed that these complexes were classified as homogeneous bidentate complexes with the general formula of [Ln2(L)2(NO3)6]·6H2O. The physical measurements indicated that the prepared complexes are non-electrolyte and paramagnetic. Some compounds prepared in vitro were evaluated for their antibacterial activity against four types of pathogenic strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia, and using the agar disc spreading method for the evaluation. The results showed that some of these complexes have good antibacterial activity compared to the biological activity of the ligand. Also, the biological activity of Schiff's base and the prepared complexes were evaluated against three types of fungi (Candida albicans, Tropical fungi, and Scandal fungi), and they showed great activity against the prepared complexes.

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4-Antipyrine Carboxaldehyde 与 2-Aminobenzothiazole 反应生成的 La(III)、Nd(III)、Er(III)、Gd(III) 和 Dy(III) 与希夫碱配合物的制备、表征和生物活性

研究包括制备几种内部过渡元素镧系元素（Ln = La、Nd、Er、Gd 和 Dy）含有 4f 外壳的络合物，以及 4-antipyrine甲醛和 2-氨基苯并噻唑缩合反应产生的希夫碱。利用傅立叶变换红外光谱、紫外-可见光谱、CHNSO 元素显微分析、核磁共振、质谱分析和 TGA 热分析鉴定了希夫碱。通过元素显微分析 CHNSO、傅立叶变换红外光谱、紫外-可见光谱、TGA 热分析、电导率测量和磁敏感度对这些配合物进行了研究和鉴定。结果表明，这些配合物属于均相双齿配合物，通式为 [Ln2(L)2(NO3)6]-6H2O。物理测量结果表明，所制备的配合物不具电解质和顺磁性。采用琼脂圆盘铺展法评估了体外制备的一些化合物对四种致病菌金黄色葡萄球菌、枯草芽孢杆菌、大肠埃希菌和肺炎克雷伯菌的抗菌活性。结果表明，与配体的生物活性相比，其中一些配合物具有良好的抗菌活性。此外，还评估了希夫碱和制备的配合物对三种真菌（白色念珠菌、热带真菌和丑陋真菌）的生物活性，结果表明它们对制备的配合物具有很强的活性。

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来源期刊

Indonesian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

11.10%

发文量

106

审稿时长

15 weeks

期刊介绍： Indonesian Journal of Chemistry is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry, applied chemistry, and chemical engineering.