Astragalus Mongholicus: A Review of its Pharmacological Mechanisms Against Gastric Cancer

IF 2.2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
J.J. Tibenda , Y. Du , Y. Nan , S. Huang , G. Chen , N. Ning , X. Li , Y. Yang , L. Yuan
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引用次数: 0

Abstract

Introduction

Astragalus membranaceus (AM) is an outstanding traditional medicinal herb that has been highly utilised for many decades in China, mainly as an adaptogen. Several medicinal functions have been associated with the components of astragalus, such as antitumour, anti-inflammatory, immune-enhancing, antioxidative, neuroprotective, and cardioprotective functions. In addition to providing future ideas on the pharmacological effects of AM in the treatment of gastric cancer (GC), this review aims to elucidate the active components of AM and its antitumour effects in GC, as well as highlight the existing experimental studies on the mechanism of AM in GC.

Methods

Literature publications relevant to the aim of the study were screened from Science Direct, PubMed, Web of Science, and Google Scholar. ‘Astragalus mongholicus,’ ‘Astragalus mongholicus, Gastric Cancer,’ ‘Astragalus Polysaccharides, Gastric Cancer,’ ‘Astragalus Saponins, Gastric Cancer,’ and ‘Flavonoids of Astragalus’ were the key terms used.

Results

Studies showed that the mechanism of action of AM in GC mainly includes suppression of cellular migration, proliferation, and invasion of GC cells. Furthermore, AM promotes cell cycle arrest and apoptosis by regulating several intracellular signalling pathways involved mainly in the immune system and inflammation.

Conclusions

The main active ingredients of AM, such as Astragalus polysaccharide, Astragaloside IV, and flavonoids like calycosin, play a major role in attenuating GC. The compounds were found to possess potent antitumour effects against GC and have to be further evaluated. Astragalus membranaceus is also a potential adjuvant chemotherapy agent.

黄芪:黄芪抗胃癌药理机制综述
导言黄芪(AM)是一种优秀的传统药材,几十年来在中国一直被广泛利用,主要作为一种适应原。黄芪的成分具有多种药用功能,如抗肿瘤、抗炎、免疫增强、抗氧化、神经保护和心脏保护功能。本综述旨在阐明黄芪的活性成分及其在胃癌中的抗肿瘤作用,并重点介绍现有关于黄芪在胃癌中的作用机制的实验研究,同时为黄芪在胃癌治疗中的药理作用提供未来思路。结果研究表明,AM对GC的作用机制主要包括抑制GC细胞的迁移、增殖和侵袭。结论 AM 的主要活性成分,如黄芪多糖、黄芪皂苷 IV 和黄酮类化合物(如钙黄苷),在减轻 GC 方面发挥了重要作用。研究发现,这些化合物对 GC 具有很强的抗肿瘤作用,有待进一步评估。膜荚黄芪还是一种潜在的辅助化疗药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Herbal Medicine
Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.90
自引率
0.00%
发文量
94
期刊介绍: The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
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