Assessment of in vitro diffusion of Chincha Lavan Taila: An Ayurveda medicated oil

Abstract

Medicated oils are used for external as well as internal administration to treat various disorders. In Ayurvedic literature Murchhana is a procedure carried out on crude oil as treatment to enhance properties of oil.  In this study, Chincha Lavan Taila a medicated formulation is prepared by two procedures Murchhita Chincha Lavan Taila (MCLT) and Amurchhita Chincha Lavan Taila (ACLT). This study aims to assess the in-vitro diffusion of Chincha Lavan Taila formulated by processed sesame oil and crude sesame oil. The in-vitro rate and extent of permeability of drug dosage forms are good markers to access the absorbance of the drug. The objective of this study is to evaluate the drug release of both oils by using in- vitro absorbance methodology of Franz diffusion cell apparatus. The in- vitro absorbance was studied in Franz diffusion cell apparatus at pH 3 and pH 8. The samples were collected and analysed under UV spectrophotometer to note absorbance of oil at different wavelength. It was noted that in the buffer solution of pH 8, there was maximum absorbance of all the samples. This experimental study shows that both formulations have well sustained absorption through gastrointestinal tract. The results indicate that the rate of absorption exhibited to be higher in MCLT compared to ACLT. This work helps to develop a new method to evaluate intestinal absorption and compare formulation for therapeutic efficacy and drug absorbance.