Structural MRI analysis of age-related changes and sex differences in marmoset brain volume

IF 2.4 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2024-09-01 DOI:10.1016/j.neures.2024.04.003

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Abstract

The field of aging biology, which aims to extend healthy lifespans and prevent age-related diseases, has turned its focus to the Callithrix jacchus (common marmoset) to understand the aging process better. This study utilized magnetic resonance imaging (MRI) to non-invasively analyze the brains of 216 marmosets, investigating age-related changes in brain structure; the relationship between body weight and brain volume; and potential differences between males and females. The key findings revealed that, similar to humans, Callithrix jacchus experiences a reduction in total intracranial volume, cortex, subcortex, thalamus, and cingulate volumes as they age, highlighting site-dependent changes in brain tissue. Notably, the study also uncovered sex differences in cerebellar volume. These insights into the structural connectivity and volumetric changes in the marmoset brain throughout aging contribute to accumulating valuable knowledge in the field, promising to inform future aging research and interventions for enhancing healthspan.

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对狨猴脑容量与年龄有关的变化和性别差异的结构性核磁共振成像分析

衰老生物学领域旨在延长健康寿命和预防与衰老相关的疾病，为了更好地了解衰老过程，该领域将重点转向了猕猴（Callithrix jacchus）。这项研究利用磁共振成像（MRI）对216只狨猴的大脑进行了无创分析，研究了与年龄有关的大脑结构变化、体重与脑容量之间的关系以及雌雄狨猴之间的潜在差异。主要研究结果表明，与人类相似，随着年龄的增长，栗鼠的颅内总容积、皮层、皮层下、丘脑和扣带回容积都会减少，这凸显了脑组织变化的部位依赖性。值得注意的是，该研究还发现了小脑体积的性别差异。这些关于狨猴大脑在整个衰老过程中的结构连接性和体积变化的见解有助于积累该领域的宝贵知识，有望为未来的衰老研究和干预措施提供信息，从而提高健康寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.