Retinal and choroidal changes after anti-VEGF therapy in neovascular-AMD patients: A systematic review and meta-analysis of SD-OCT studies

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY
Mohammad Amin Salehi , Negin Frounchi , Seyed Sina Zakavi , Soheil Mohammadi , Hamid Harandi , Shayan Shojaei , Mahdi Gouravani , J. Fernando Arevalo
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Abstract

Background

In recent years, the progress made in the field of optical coherence tomography has helped to understand the changes in eye layers in patients with exudative age-related macular degeneration (nAMD). Early diagnosis of nAMD, a leading cause of irreversible vision impairment, is helpful. Therefore, we performed a meta-analysis on OCT measurement alterations before and after anti-VEGF therapy in patients with nAMD and controls.

Method

We systematically searched Scopus, PubMed, Cochrane, and Web of Science to find articles that measured choroidal and retinal layer changes after anti-VEGF therapy in nAMD Patients. We chose either a fixed-effects or random-effects model based on the assessed heterogeneity level to perform a meta-analysis. In addition, we conducted meta-regression, subgroup analyses, publication bias, and quality assessment for included studies.

Results

Thirteen studies were included in the meta-analysis, with 733 total participants. Foveal thickness and subfoveal choroidal thickness (CT) decreased significantly in the first 3 years after injections, except for subfoveal CT in the third year after injection. It also showed that CT at 1500 µm temporal and nasal to the fovea did not significantly change.

Conclusion

Our results showed anti-VEGF treatment for nAMD patients was associated with a significant reduction in foveal thickness and subfoveal CT in the first 2 years after treatment. Our analysis did not reveal any correlation between changes in foveal thickness and subfoveal CT with best-corrected visual acuity or other factors.

抗血管内皮生长因子治疗后新生血管性黄斑变性患者视网膜和脉络膜的变化:SD-OCT研究的系统回顾和元分析。
背景近年来,光学相干断层扫描领域取得的进展有助于了解渗出性年龄相关性黄斑变性(nAMD)患者眼球各层的变化。nAMD 是造成不可逆视力损伤的主要原因之一,早期诊断 nAMD 会有所帮助。因此,我们对nAMD患者和对照组在接受抗血管内皮生长因子治疗前后的OCT测量变化进行了荟萃分析。方法我们系统地检索了Scopus、PubMed、Cochrane和Web of Science,以找到测量nAMD患者接受抗血管内皮生长因子治疗后脉络膜和视网膜层变化的文章。我们根据评估的异质性水平选择了固定效应或随机效应模型进行荟萃分析。此外,我们还对纳入的研究进行了荟萃回归、亚组分析、发表偏倚和质量评估。结果荟萃分析纳入了 13 项研究,共有 733 名参与者。在注射后的前 3 年中,眼窝厚度和眼底脉络膜厚度(CT)显著下降,但眼底 CT 在注射后的第 3 年显著下降。结论我们的研究结果表明,对 nAMD 患者进行抗 VEGF 治疗与治疗后头两年眼窝厚度和眼底 CT 的显著降低有关。我们的分析没有发现眼窝厚度和眼窝下 CT 的变化与最佳矫正视力或其他因素有任何关联。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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