Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum: A Literature Review

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-04 DOI:10.1097/fm9.0000000000000221

Putri Mirani, P. M. Lestari, K. Murti, I. Liberty, Hana Andrina, Cindy Kesty, Bella Stevanny

引用次数: 0

Abstract

The recent increase in placenta accreta spectrum has been correlated with a rise in the rate of cesarean sections. A recent study provides evidence that hampered wound healing results in cesarean scar defects that lead to a failure in the normal process of decidualization and deeper adherence of trophoblasts. Matrix metalloproteinase (MMP) is crucial in every step of wound healing as it alters the wound matrix, facilitating cell migration, as well as tissue remodeling. MMP-9 expression is higher in placental and decidual tissue in cases of placenta accreta. Based on these findings, assessment of MMP-9 expression can shed new light on the etiopathology of placenta accreta spectrum disorder and can be a potential diagnostic marker.

查看原文本刊更多论文

基质金属蛋白酶-9在胎盘早剥综合征发病机制中的作用：文献综述

近年来，胎盘早剥谱的增加与剖宫产率的上升有关。最近的一项研究提供了证据，表明伤口愈合受阻会导致剖宫产瘢痕缺损，从而导致蜕膜化和滋养细胞深层粘附的正常过程失败。基质金属蛋白酶（MMP）在伤口愈合的每一步中都至关重要，因为它能改变伤口基质，促进细胞迁移和组织重塑。在胎盘早剥病例中，胎盘和蜕膜组织中的 MMP-9 表达较高。基于这些发现，评估 MMP-9 的表达可为胎盘早剥谱系障碍的病因病理学提供新的线索，并可作为一种潜在的诊断标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.