Epigenetics in Cancer Therapy

International Journal of Trends in OncoScience Pub Date : 2024-04-05 DOI:10.22376/ijtos.2024.2.2.32-40

Dr. Abikesh Prasada Kumar Mahapatra, Vinod S. Mule, Dr Avula Naveen, Dr. Somenath Ghosh

{"title":"Epigenetics in Cancer Therapy","authors":"Dr. Abikesh Prasada Kumar Mahapatra, Vinod S. Mule, Dr Avula Naveen, Dr. Somenath Ghosh","doi":"10.22376/ijtos.2024.2.2.32-40","DOIUrl":null,"url":null,"abstract":"Epigenetics regulates parts of the genetic information accessible to cellular machinery, thus contributing to cellular diversity. Disruption of epigenetic harmonisation can lead to dysregulation of signaling pathways and contribute to diseases like cancer. Epigenetic processes are crucial in coordinating the normal growth and preservation of gene activity unique to mammal tissues. Epigenetic studies in current cancer research are vital for early detection through biomarker identification, understanding tumor heterogeneity, predicting treatment responses, and uncovering resistance mechanisms. This knowledge informs targeted therapies, enhances personalized medicine, and improves overall outcomes in cancer patients. This review comprehensively explores epigenetic processes in healthy cells, emphasizing histone modification-lysine acetylation and DNA methylation. The intricate mechanisms governing genetic expression and their dysregulation in cancer progression are also reviewed. Examining prevalent cancer types, this review stresses the pivotal role of epigenetics in understanding and potentially targeting these processes for therapeutic interventions.","PeriodicalId":479912,"journal":{"name":"International Journal of Trends in OncoScience","volume":"5 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Trends in OncoScience","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.22376/ijtos.2024.2.2.32-40","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

Epigenetics regulates parts of the genetic information accessible to cellular machinery, thus contributing to cellular diversity. Disruption of epigenetic harmonisation can lead to dysregulation of signaling pathways and contribute to diseases like cancer. Epigenetic processes are crucial in coordinating the normal growth and preservation of gene activity unique to mammal tissues. Epigenetic studies in current cancer research are vital for early detection through biomarker identification, understanding tumor heterogeneity, predicting treatment responses, and uncovering resistance mechanisms. This knowledge informs targeted therapies, enhances personalized medicine, and improves overall outcomes in cancer patients. This review comprehensively explores epigenetic processes in healthy cells, emphasizing histone modification-lysine acetylation and DNA methylation. The intricate mechanisms governing genetic expression and their dysregulation in cancer progression are also reviewed. Examining prevalent cancer types, this review stresses the pivotal role of epigenetics in understanding and potentially targeting these processes for therapeutic interventions.

查看原文本刊更多论文

癌症治疗中的表观遗传学

表观遗传学调节细胞机制可获取的部分遗传信息，从而促进细胞多样性。表观遗传协调的破坏会导致信号通路失调，引发癌症等疾病。表观遗传过程在协调正常生长和保持哺乳动物组织特有的基因活性方面至关重要。目前癌症研究中的表观遗传学研究对于通过生物标志物鉴定进行早期检测、了解肿瘤异质性、预测治疗反应和揭示抗药性机制至关重要。这些知识为靶向治疗提供了信息，增强了个性化医疗，并改善了癌症患者的整体预后。这篇综述全面探讨了健康细胞的表观遗传过程，重点是组蛋白修饰--赖氨酸乙酰化和DNA甲基化。此外，还综述了基因表达的复杂机制及其在癌症进展过程中的失调。通过对常见癌症类型的研究，本综述强调了表观遗传学在理解和针对这些过程进行治疗干预方面的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Trends in OncoScience

自引率

0.00%

发文量