Sex differences in CD8+ T cell responses during adaptive immunity.

IF 4.6 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

WIREs Mechanisms of Disease Pub Date : 2024-04-05 DOI:10.1002/wsbm.1645

Paul Jerard Layug, Harman Vats, Kamali Kannan, J. Arsenio

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Abstract

Biological sex is an important variable that influences the immune system's susceptibility to infectious and non-infectious diseases and their outcomes. Sex dimorphic features in innate and adaptive immune cells and their activities may help to explain sex differences in immune responses. T lymphocytes in the adaptive immune system are essential to providing protection against infectious and chronic inflammatory diseases. In this review, T cell responses are discussed with focus on the current knowledge of biological sex differences in CD8+ T cell mediated adaptive immune responses in infectious and chronic inflammatory diseases. Future directions aimed at investigating the molecular and cellular mechanisms underlying sex differences in diverse T cell responses will continue to underscore the significance of understanding sex differences in protective immunity at the cellular level, to induce appropriate T cell-based immune responses in infection, autoimmunity, and cancer. This article is categorized under: Immune System Diseases > Molecular and Cellular Physiology Infectious Diseases > Molecular and Cellular Physiology.

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适应性免疫过程中 CD8+ T 细胞反应的性别差异。

生物性别是影响免疫系统对传染性和非传染性疾病的易感性及其结果的一个重要变量。先天性和适应性免疫细胞的性别二形特征及其活动可能有助于解释免疫反应的性别差异。适应性免疫系统中的 T 淋巴细胞对预防感染性和慢性炎症性疾病至关重要。本综述讨论了 T 细胞的反应，重点是目前对 CD8+ T 细胞介导的适应性免疫反应在传染病和慢性炎症性疾病中的生物学性别差异的认识。未来研究各种 T 细胞反应中性别差异的分子和细胞机制的方向将继续强调从细胞水平了解保护性免疫中性别差异的重要性，从而在感染、自身免疫和癌症中诱导适当的基于 T 细胞的免疫反应。本文归类于免疫系统疾病 > 分子和细胞生理学传染性疾病 > 分子和细胞生理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

11.40

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0.00%

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