Current Trends and Advancements in the Management of Hepatocellular Carcinoma.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases Pub Date : 2024-04-10 DOI:10.1159/000538815

A. Teufel, Masatoshi Kudo, Yuquan Qian, J. Daza, Isaac Rodriguez, Christoph Reissfelder, E. Ridruejo, M. P. Ebert

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引用次数: 0

Abstract

Hepatocellular Carcinoma (HCC) remains a significant global health burden with a high mortality rate. Over the past 40 years, significant progress has been achieved in the prevention and management of HCC. Hepatitis B vaccination programs, the development of direct acting antiviral drugs for Hepatitis C and effective surveillance strategies provide a profound basis for prevention for HCC. Advanced surgery and liver transplantation along with local ablation techniques potentially offer cure for the disease, Also just recently, the introduction of immunotherapy opened a new chapter in systemic treatment. Finally, the introduction of the BCLC classification system for HCC, clearly defining patient groups and assigning reasonable treatment options, has standardized treatment and become the basis of almost all clinical trials for HCC. With this review, we provide a comprehensive overview of the evolving landscape of HCC management but also touch on current challenges. A comprehensive and multidisciplinary approach is crucial for effective HCC management. Continued research and clinical trials are imperative to further enhance treatment options and will ultimately reduce the global burden of this devastating disease.

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肝细胞癌治疗的当前趋势和进展。

肝细胞癌（HCC）仍然是全球健康的重大负担，死亡率很高。过去 40 年来，HCC 的预防和管理取得了重大进展。乙型肝炎疫苗接种计划、丙型肝炎直接作用抗病毒药物的开发以及有效的监测策略为预防 HCC 提供了深厚的基础。先进的外科手术和肝移植以及局部消融技术有可能治愈这种疾病，而且就在最近，免疫疗法的引入为全身治疗揭开了新的篇章。最后，BCLC HCC 分类系统的引入，明确定义了患者分组并分配了合理的治疗方案，规范了治疗，几乎成为所有 HCC 临床试验的基础。通过这篇综述，我们全面概述了不断发展的 HCC 治疗情况，同时也谈到了当前面临的挑战。综合的多学科方法对于有效治疗 HCC 至关重要。持续的研究和临床试验对于进一步改进治疗方案势在必行，并将最终减轻这种毁灭性疾病给全球带来的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases 医学-胃肠肝病学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.