Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-04-10 DOI:10.5271/sjweh.4161

M. Guth, Corinne Pilorget, Marie Lefevre, Astrid Coste, A. Danjou, B. Dananché, D. Praud, O. Pérol, Myriam Daudin, Marie-Ange Clarotti, Stéphanie Lattes, Céline Bouillon, Adèle Paul, J. Schüz, Louis Bujan, A. Olsson, Béatrice Fervers, B. Charbotel

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Abstract

OBJECTIVES Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men. METHODS This study examined occupational exposures to solvents and TGCT risk based on the lifetime work histories of 454 cases and 670 controls, aged 18-45 years, of the French national TESTIS case-control study. Solvent exposure was estimated using: (i) exposure assignment by job-exposure matrix (JEM) and (ii) JEM combined with self-reported exposure data from specific questionnaires (SQ) and expert assessment (EA). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models. RESULTS Both approaches (JEM and JEM+SQ+EA) showed a consistent association between TGCT and trichloroethylene exposure (exposed versus not exposed; JEM=OR 1.80 [95% confidence interval (CI) 1.12-2.90] and JEM+SQ+EA= OR 2.59 (95% CI 1.42-4.72). Both approaches also observed positive associations with ketone esters and fuels & petroleum-based solvents. CONCLUSION The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.

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有机溶剂的职业暴露与睾丸生殖细胞肿瘤的发病风险（TESTIS 研究）：综合暴露评估对风险估计的影响。

目的睾丸生殖细胞瘤（TGCT）的致病因素在很大程度上仍然未知，但有人认为职业性接触溶剂可能是其致病因素。以前对这些暴露进行分析的研究报告了不一致的结果，这可能与暴露评估方法有关。本研究旨在调查溶剂职业暴露对年轻男性罹患 TGCT 风险的影响。方法本研究根据法国全国 TESTIS 病例对照研究中 454 例病例和 670 例对照（年龄在 18-45 岁之间）的终生工作史，对溶剂职业暴露和 TGCT 风险进行了调查。溶剂暴露的估算方法包括：(i) 通过工作-暴露矩阵（JEM）进行暴露分配；(ii) 将工作-暴露矩阵与来自特定问卷（SQ）和专家评估（EA）的自我报告暴露数据相结合。结果两种方法（JEM 和 JEM+SQ+EA）均显示 TGCT 与三氯乙烯暴露（暴露与未暴露；JEM=OR 1.80 [95% 置信区间 (CI) 1.12-2.90]，JEM+SQ+EA=OR 2.59 (95% CI 1.42-4.72)）之间存在一致的关联。结果表明，一些有机溶剂可能与职业暴露男性 TGCT 的发病机制有关。联合使用JEM+SQ+EA似乎可以通过考虑个体暴露变异性来限制误分类，因此是流行病学研究中评估职业暴露的一种有吸引力的方法。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.