Hematopoietic Clonal Evolution Goes Spatial.

IF 11.5 Q1 HEMATOLOGY

Blood Cancer Discovery Pub Date : 2024-04-22 DOI:10.1158/2643-3230.BCD-24-0057

Rebecca Austin, I. Aifantis

引用次数: 0

Abstract

SUMMARY The spatial distribution of cells carrying clonal hematopoiesis mutations in the bone marrow and the potential role of interactions with the microenvironment are largely unknown. This study takes clonal evolution to the spatial level by describing a novel technique examining the spatial location of mutated clones in the bone marrow and the first evidence that mutated hematopoietic clones are spatially constrained and have heterogenous locations within millimeters of distance. See related article by Young et al., p. 153 (10).

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造血干细胞克隆进化的空间演变

摘要骨髓中携带克隆造血突变的细胞的空间分布以及与微环境相互作用的潜在作用在很大程度上是未知的。这项研究将克隆进化提升到空间层面，描述了一种检查骨髓中突变克隆空间位置的新技术，并首次证明突变造血克隆受空间限制，在几毫米的距离内具有不同的位置。参见 Young 等人的相关文章，第 153 页（10）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Cancer Discovery Multiple-

CiteScore

12.70

自引率

1.80%

发文量

139

期刊介绍： The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.