Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-04-25 DOI:10.1038/s41429-024-00727-1

Teppei Kawahara, Kanako Saita, Rika Iwamoto, Mikiyo Wada

引用次数: 0

Abstract

Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, as well as HRESI-MS, UV and IR, and comparison with data reported in the literature. Compound 1 and benastatins A and B exhibited inhibitory activity against Micrococcus luteus (MIC 7.8, 31.3, and 3.9 μM, respectively), and IgE-mediated β-hexosaminidase release in RBL-2H3 cells with IC50 values of 42, 79, and 19 μM, respectively.

Abstract Image

查看原文本刊更多论文

贝那斯汀 K，一种来自链霉菌 HGTA384 的氯化贝那斯汀相关抗生素。

从放线菌 Streptomyces sp. HGTA384 的培养液中分离出了一种新的氯化苯司他丁衍生物--苯司他丁 K（1）。根据光谱分析（包括一维和二维核磁共振以及 HRESI-MS、紫外和红外光谱）以及与文献报道数据的比较，确定了 1 的结构。化合物 1 和贝那斯汀 A 和 B 对黄体微球菌（MIC 分别为 7.8、31.3 和 3.9 μM）和 RBL-2H3 细胞中 IgE 介导的 β-己糖胺酸酶释放具有抑制活性，IC50 值分别为 42、79 和 19 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.