Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma: A comprehensive review

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jing-Jing Li, Jiaxi Mao, Han-Xiang Zhong, Yuan-Yu Zhao, Fei Teng, Xin-Yi Lu, Li-Ye Zhu, Yang Gao, Hong Fu, Wen-yuan Guo
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引用次数: 0

Abstract

The tumor microenvironment is a complex network of cells, extracellular matrix, and signaling molecules that plays a critical role in tumor progression and metastasis. Lymphatic and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage conduits. However, recent studies have shown that lymphatic endothelial cells (LECs) and blood endothelial cells (BECs) also play multifaceted roles in the tumor microenvironment beyond their structural functions, particularly in hepatocellular carcinoma (HCC). This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC, including their involvement in angiogenesis, immune modulation, lymphangiogenesis, and metastasis. By providing a detailed account of the complex interplay between LECs, BECs, and tumor cells, this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.
淋巴和血液内皮细胞在肝细胞癌肿瘤微环境中的多重作用:综述
肿瘤微环境是由细胞、细胞外基质和信号分子组成的复杂网络,在肿瘤进展和转移过程中起着至关重要的作用。淋巴和血管是实体瘤转移的主要途径,也是肿瘤引流管道的重要组成部分。然而,最近的研究表明,淋巴内皮细胞(LECs)和血液内皮细胞(BECs)在肿瘤微环境中也发挥着结构功能以外的多方面作用,尤其是在肝细胞癌(HCC)中。这篇综述总结了 LECs 和 BECs 在 HCC 中发挥的各种作用,包括参与血管生成、免疫调节、淋巴管生成和转移。本综述详细阐述了 LECs、BECs 和肿瘤细胞之间复杂的相互作用,旨在阐明 LECs 免疫调节功能的未来研究方向以及 HCC 的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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