Metabolic Messengers: Thyroid Hormones

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-04-26 DOI:10.1038/s42255-024-00986-0

Rohit A. Sinha, Paul M. Yen

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Abstract

Thyroid hormones (THs) are key hormones that regulate development and metabolism in mammals. In man, the major target tissues for TH action are the brain, liver, muscle, heart, and adipose tissue. Defects in TH synthesis, transport, metabolism, and nuclear action have been associated with genetic and endocrine diseases in man. Over the past few years, there has been renewed interest in TH action and the therapeutic potential of THs and thyromimetics to treat several metabolic disorders such as hypercholesterolemia, dyslipidaemia, non-alcoholic fatty liver disease (NAFLD), and TH transporter defects. Recent advances in the development of tissue and TH receptor isoform-targeted thyromimetics have kindled new hope for translating our fundamental understanding of TH action into an effective therapy. This review provides a concise overview of the historical development of our understanding of TH action, its physiological and pathophysiological effects on metabolism, and future therapeutic applications to treat metabolic dysfunction. Sinha and Yen provide a comprehensive overview of thyroid hormones and their role in development and in regulation of whole-body metabolic homeostasis

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代谢信使甲状腺激素

甲状腺激素（THs）是调节哺乳动物发育和新陈代谢的关键激素。在人体内，TH 作用的主要靶组织是大脑、肝脏、肌肉、心脏和脂肪组织。TH合成、运输、代谢和核作用的缺陷与人类的遗传和内分泌疾病有关。在过去几年中，人们对 TH 的作用以及 THs 和甲状腺拟态物质治疗多种代谢性疾病（如高胆固醇血症、血脂异常、非酒精性脂肪肝和 TH 转运体缺陷）的潜力重新产生了兴趣。组织和TH受体同工酶靶向甲状腺仿生学的最新进展为将我们对TH作用的基本认识转化为有效疗法带来了新希望。本综述简明扼要地概述了我们对甲状腺激素作用认识的历史发展、甲状腺激素对新陈代谢的生理和病理生理学影响以及未来治疗代谢功能障碍的疗法应用。Sinha和Yen全面概述了甲状腺激素及其在发育和调节全身代谢平衡中的作用。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.