Tenascin-C targeting strategies in cancer

IF 4.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology Pub Date : 2024-04-18 DOI:10.1016/j.matbio.2024.04.002

Sayda Dhaouadi , Balkiss Bouhaouala-Zahar , Gertraud Orend

引用次数: 0

Abstract

Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.

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癌症中的 Tenascin-C 靶向策略

Tenascin-C（TNC）是一种在病理条件下，尤其是在癌症和慢性炎症性疾病中高度表达的母细胞多模态糖蛋白。长期以来，TNC 被认为是抗癌治疗中诊断和治疗方法的一个有前途的靶点，并已在癌症患者的临床试验中广泛应用。本综述概述了目前用于 TNC 检测和抗 TNC 治疗方法的最先进策略，包括一些先进的临床策略。我们还讨论了以 TNC 的免疫调节功能为靶点的新型治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Matrix Biology 生物-生化与分子生物学

CiteScore

11.40

自引率

4.30%

发文量

审稿时长

45 days

期刊介绍： Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.