Nanoparticles-based double-stranded RNA delivery as an antiviral agent in shrimp aquaculture

IF 8.8 1区 农林科学 Q1 FISHERIES
Veasarach Jonjaroen, Patai Charoonnart, Sarocha Jitrakorn, Panwajee Payongsri, Rudee Surarit, Vanvimon Saksmerprome, Nuttawee Niamsiri
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Abstract

The review encapsulates the comprehensive exploration of RNA interference technology's application in shrimp aquaculture, covering molecular intricacies, production methods, and practical applications. The emphasis is on exploring the stability and delivery of gene-specific double-stranded RNA, particularly through nanoencapsulation. This is because the susceptibility of dsRNA to degradation and limited cellular penetration, emphasising the need for effective delivery mechanisms. The review presents an in-depth exploration of nanoparticles for the encapsulation and delivery of dsRNA, including virus-like particles (VLPs), and non-viral based nanoparticles such as liposomes, chitosan, and beta-glucan. VLPs, derived from non-infectious shrimp virus structures, exhibit biocompatibility and natural functionality, making them suitable carriers for dsRNA. The application of chitosan and its derivatives are explored for their efficacy in reducing viral infections in shrimp. Beta-glucan particles are examined for their immunostimulant properties in shrimp aquaculture. The text emphasises the use of yeast-based glucan particles for encapsulating dsRNA, showcasing their potential in preventing viral diseases in shrimp. The review introduces cautionary considerations for nanoparticle formulation, highlighting factors such as pH, organic solvents, metal ions, and environmental ribonuclease that can impact dsRNA stability during synthesis. In conclusion, the text discusses the potential economic worthiness and environmental risk assessment of dsRNA technology in shrimp aquaculture. While acknowledging successful applications in other environments, it underscores the need for regulatory approval and risk assessment for dsRNA-based products in the aquaculture industry. The evaluation of dsRNA in real-world shrimp farms is deemed necessary for commercial utilisation, taking into account income, expenses, safety, and environmental considerations.

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将基于纳米颗粒的双链 RNA 递送作为对虾养殖中的抗病毒剂
这篇综述全面探讨了 RNA 干扰技术在对虾养殖中的应用,涵盖了分子的复杂性、生产方法和实际应用。重点是探索基因特异性双链 RNA 的稳定性和输送,特别是通过纳米封装。这是因为 dsRNA 易于降解,细胞穿透力有限,因此需要有效的递送机制。本综述深入探讨了用于封装和递送 dsRNA 的纳米颗粒,包括病毒样颗粒(VLPs)和非病毒类纳米颗粒,如脂质体、壳聚糖和β-葡聚糖。VLPs 源自非感染性虾病毒结构,具有生物相容性和天然功能性,是 dsRNA 的合适载体。我们探讨了壳聚糖及其衍生物在减少对虾病毒感染方面的应用。研究了β-葡聚糖颗粒在对虾养殖中的免疫刺激特性。文中强调使用基于酵母的葡聚糖颗粒封装 dsRNA,展示其在预防对虾病毒性疾病方面的潜力。综述介绍了纳米颗粒配方的注意事项,强调了 pH 值、有机溶剂、金属离子和环境核糖核酸酶等会在合成过程中影响 dsRNA 稳定性的因素。最后,文章讨论了 dsRNA 技术在对虾养殖中的潜在经济价值和环境风险评估。在肯定其他环境中的成功应用的同时,它强调了水产养殖业中基于 dsRNA 产品的监管审批和风险评估的必要性。考虑到收入、支出、安全和环境因素,在实际对虾养殖场对 dsRNA 进行评估被认为是商业利用的必要条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
24.80
自引率
5.80%
发文量
109
审稿时长
>12 weeks
期刊介绍: Reviews in Aquaculture is a journal that aims to provide a platform for reviews on various aspects of aquaculture science, techniques, policies, and planning. The journal publishes fully peer-reviewed review articles on topics including global, regional, and national production and market trends in aquaculture, advancements in aquaculture practices and technology, interactions between aquaculture and the environment, indigenous and alien species in aquaculture, genetics and its relation to aquaculture, as well as aquaculture product quality and traceability. The journal is indexed and abstracted in several databases including AgBiotech News & Information (CABI), AgBiotechNet, Agricultural Engineering Abstracts, Environment Index (EBSCO Publishing), SCOPUS (Elsevier), and Web of Science (Clarivate Analytics) among others.
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