Factors Influencing Serum Posaconazole Concentrations in Patients with Hematologic Malignancies Receiving Delayed-Release Tablets.

IF 2.8 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Therapeutic Drug Monitoring Pub Date : 2024-04-04 DOI:10.1097/ftd.0000000000001196

Takaaki Yamada, Tassadit Belabbas, Kimitaka Suetsugu, Takeshi Hirota, Yasuo Mori, Koji Kato, Koichi Akashi, Nobuaki Egashira, Ichiro Ieiri

引用次数: 0

Abstract

Posaconazole (PCZ) plays a crucial role in the prophylaxis and treatment of invasive fungal infections in hematologic malignancies. PCZ concentrations reportedly vary among patients receiving delayed-release tablets (DRT). However, the factors influencing these concentrations remain insufficiently elucidated. Therefore, this study aimed to evaluate the factors influencing PCZ concentrations and their effect on the probability of target attainment (PTA) using a population pharmacokinetic (PPK) approach. We also explored the relationship between PCZ exposure and hepatotoxicity.

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影响服用缓释片的血液恶性肿瘤患者血清泊沙康唑浓度的因素

泊沙康唑（PCZ）在血液系统恶性肿瘤侵袭性真菌感染的预防和治疗中发挥着重要作用。据报道，接受缓释片（DRT）治疗的患者体内 PCZ 浓度各不相同。然而，影响这些浓度的因素仍未得到充分阐明。因此，本研究旨在采用群体药代动力学（PPK）方法评估影响 PCZ 浓度的因素及其对达标概率（PTA）的影响。我们还探讨了 PCZ 暴露与肝毒性之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Drug Monitoring 医学-毒理学

CiteScore

5.00

自引率

8.00%

发文量

213

审稿时长

4-8 weeks

期刊介绍： Therapeutic Drug Monitoring is a peer-reviewed, multidisciplinary journal directed to an audience of pharmacologists, clinical chemists, laboratorians, pharmacists, drug researchers and toxicologists. It fosters the exchange of knowledge among the various disciplines–clinical pharmacology, pathology, toxicology, analytical chemistry–that share a common interest in Therapeutic Drug Monitoring. The journal presents studies detailing the various factors that affect the rate and extent drugs are absorbed, metabolized, and excreted. Regular features include review articles on specific classes of drugs, original articles, case reports, technical notes, and continuing education articles.