Novel agents and regimens in relapsed or refractory peripheral T-cell lymphoma: latest updates from 2023 ASH annual meeting

IF 9.4 1区医学 Q1 HEMATOLOGY

Experimental Hematology & Oncology Pub Date : 2024-04-22 DOI:10.1186/s40164-024-00510-w

Huageng Huang, Wei Zhang, Xinyi Deng, He Huang, Zhao Wang, Huangming Hong, Tongyu Lin

引用次数: 0

Abstract

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of hematological malignancies with poor survival, while treatment options for relapsed or refractory (R/R) disease remain quite limited, with a median progression-free survival of only 3–4 months. Notably, the emergence of innovative therapeutic agents and regimens holds promise for durable responses and improved survival for patients with R/R PTCL. We summarize recent advances in the treatment of R/R PTCL from the 2023 ASH Annual Meeting, highlighting novel agents targeting EZH1/2, JAK1, PI3K, KIR3DL2, CD38/CD3xCD28, or CDK9, as well as therapeutic regimens in combination with stem cell transplantation, immunomodulators, epigenetic modifying agents, or CD30/CD16A bispecific antibodies.

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复发或难治性外周T细胞淋巴瘤的新型药物和治疗方案：2023年ASH年会的最新进展

外周 T 细胞淋巴瘤（PTCL）是一种异质性血液恶性肿瘤，生存率很低，而复发或难治性（R/R）疾病的治疗方案仍然非常有限，中位无进展生存期仅为 3-4 个月。值得注意的是，创新治疗药物和方案的出现为复发性或难治性 PTCL 患者带来了持久应答和改善生存的希望。我们总结了2023年ASH年会上治疗R/R PTCL的最新进展，重点介绍了靶向EZH1/2、JAK1、PI3K、KIR3DL2、CD38/CD3xCD28或CDK9的新型药物，以及与干细胞移植、免疫调节剂、表观遗传修饰药物或CD30/CD16A双特异性抗体相结合的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Hematology & Oncology Medicine-Oncology

CiteScore

12.60

自引率

7.30%

发文量

审稿时长

6 weeks

期刊介绍： Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings. Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.