Relevant Developments in the Use of Three-Component Reactions for the Total Synthesis of Natural Products. The last 15 Years

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2024-04-22 DOI:10.1002/open.202300306

Prof. Enrique L. Larghi, Dr. Andrea B. J. Bracca, Dr. Sebastian O. Simonetti, Prof. Teodoro S. Kaufman

引用次数: 0

Abstract

Multicomponent reactions (MCRs) offer a highly useful and valuable strategy that can fulfill an important role in synthesizing complex polysubstituted compounds, by simplifying otherwise long sequences and increasing their efficiency. The total synthesis of selected natural products employing three-component reactions as their common strategic MCR approach, is reviewed on a case-by-case basis with selected targets conquered during the last 15 years. The revision includes detailed descriptions of the selected successful sequences; relevant information on the isolation, and bioactivity of the different natural targets is also briefly provided.

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利用三组分反应进行天然产物全合成的相关进展。过去 15 年

多组分反应（MCR）提供了一种非常有用和有价值的策略，它可以简化原本冗长的序列并提高其效率，从而在合成复杂的多取代化合物方面发挥重要作用。本报告以过去 15 年中攻克的选定目标为基础，逐一回顾了采用三组分反应作为 MCR 常用战略方法的选定天然产物的全合成过程。修订内容包括对所选成功序列的详细描述；还简要介绍了不同天然靶标的分离和生物活性的相关信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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